在迟发型超敏反应诱导过程中协同作用的T细胞通过对抗原决定簇的连锁识别发挥作用。
T cells cooperating in the induction of delayed-type hypersensitivity act via the linked recognition of antigenic determinants.
作者信息
Tucker M J, Bretscher P A
出版信息
J Exp Med. 1982 Apr 1;155(4):1037-49. doi: 10.1084/jem.155.4.1037.
Abstract
Culture conditions have been established that allow the induction of delayed-type hypersensitivity (DTH) precursor cells present in a cell population derived from unsensitized spleen cells only when antigen-specific, radioresistant, Thy-1-bearing helper cells are added. This specific cellular cooperation acts via the linked recognition of two determinants on the antigen; thus, cells primed to the protein antigen fowl gamma globulin (FGG) will only allow the induction of DTH reactivity against the second antigen, burro erythrocyte (BRBC), when the conjugate FGG-BRBC is present in the cultures. The requirement for physical linkage between the two antigens has been demonstrated by the observation that DTH to BRBC is induced when the conjugate FGG-BRBC is present and not when BRBC and FGG are given an uncoupled molecules.
摘要
已经建立了培养条件，只有当加入抗原特异性、抗辐射、携带Thy-1的辅助细胞时，才能诱导存在于未致敏脾细胞来源的细胞群体中的迟发型超敏反应（DTH）前体细胞。这种特异性细胞协作通过对抗原上两个决定簇的连锁识别起作用；因此，用蛋白抗原鸡γ球蛋白（FGG）致敏的细胞只有在培养物中存在结合物FGG-BRBC时，才会诱导对第二种抗原驴红细胞（BRBC）的DTH反应性。当结合物FGG-BRBC存在时可诱导对BRBC的DTH，而当BRBC和FGG以未偶联分子形式给予时则不能诱导，这一观察结果证明了两种抗原之间物理连接的必要性。
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