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在迟发型超敏反应诱导过程中协同作用的T细胞通过对抗原决定簇的连锁识别发挥作用。

T cells cooperating in the induction of delayed-type hypersensitivity act via the linked recognition of antigenic determinants.

作者信息

Tucker M J, Bretscher P A

出版信息

J Exp Med. 1982 Apr 1;155(4):1037-49. doi: 10.1084/jem.155.4.1037.

DOI:10.1084/jem.155.4.1037
PMID:6174668
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2186653/
Abstract

Culture conditions have been established that allow the induction of delayed-type hypersensitivity (DTH) precursor cells present in a cell population derived from unsensitized spleen cells only when antigen-specific, radioresistant, Thy-1-bearing helper cells are added. This specific cellular cooperation acts via the linked recognition of two determinants on the antigen; thus, cells primed to the protein antigen fowl gamma globulin (FGG) will only allow the induction of DTH reactivity against the second antigen, burro erythrocyte (BRBC), when the conjugate FGG-BRBC is present in the cultures. The requirement for physical linkage between the two antigens has been demonstrated by the observation that DTH to BRBC is induced when the conjugate FGG-BRBC is present and not when BRBC and FGG are given an uncoupled molecules.

摘要

已经建立了培养条件，只有当加入抗原特异性、抗辐射、携带Thy-1的辅助细胞时，才能诱导存在于未致敏脾细胞来源的细胞群体中的迟发型超敏反应（DTH）前体细胞。这种特异性细胞协作通过对抗原上两个决定簇的连锁识别起作用；因此，用蛋白抗原鸡γ球蛋白（FGG）致敏的细胞只有在培养物中存在结合物FGG-BRBC时，才会诱导对第二种抗原驴红细胞（BRBC）的DTH反应性。当结合物FGG-BRBC存在时可诱导对BRBC的DTH，而当BRBC和FGG以未偶联分子形式给予时则不能诱导，这一观察结果证明了两种抗原之间物理连接的必要性。

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T cells cooperating in the induction of delayed-type hypersensitivity act via the linked recognition of antigenic determinants.在迟发型超敏反应诱导过程中协同作用的T细胞通过对抗原决定簇的连锁识别发挥作用。
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本文引用的文献

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The carrier effect in the secondary response to hapten-protein conjugates. II. Cellular cooperation.对半抗原-蛋白质偶联物二次应答中的载体效应。II. 细胞协作。
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Delayed hypersensitivity to hapten-protein conjugates. I. The effect of carrier protein and site of attachment to hapten.对半抗原 - 蛋白质结合物的迟发型超敏反应。I. 载体蛋白及与半抗原连接位点的影响
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The specificity of allergic reactions. I. Delayed versus Arthus hypersensitivity.过敏反应的特异性。I. 迟发型超敏反应与阿瑟斯超敏反应
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Effect of helper T cells on the primary in vitro production of delayed-type hypersensitivity to influenza virus.辅助性T细胞对流感病毒迟发型超敏反应体外初次产生的影响。
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Thymus-marrow cell combinations. Synergism in antibody production.胸腺-骨髓细胞组合。抗体产生中的协同作用。
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Cell to cell interaction in the immune response. 3. Chromosomal marker analysis of single antibody-forming cells in reconstituted, irradiated, or thymectomized mice.免疫反应中的细胞间相互作用。3. 对重建、照射或胸腺切除小鼠体内的单个抗体形成细胞进行染色体标记分析。
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Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes.免疫反应中的细胞间相互作用。II. 给受照射小鼠输注骨髓、胸腺或胸导管淋巴细胞后溶血素形成细胞的来源。
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Absorption of guinea pig serum with agar. A method for elimination of itscytotoxicity for murine thymus cells.用琼脂吸收豚鼠血清。一种消除其对小鼠胸腺细胞细胞毒性的方法。
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Proc Natl Acad Sci U S A. 1971 Apr;68(4):699-703. doi: 10.1073/pnas.68.4.699.
10
The immune response of normal, irradiated and thymectomized mice to fowl immunoglobulin G as detected by a hemolytic plaque technique.通过溶血空斑技术检测正常、经辐射及胸腺切除小鼠对鸡免疫球蛋白G的免疫反应。
Int Arch Allergy Appl Immunol. 1971;40(1):59-71. doi: 10.1159/000230395.