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1
Evidence for circularization of the avian oncornavirus RNA genome during proviral DNA synthesis from studies of reverse transcription in vitro.通过体外逆转录研究获得的证据表明，禽肿瘤病毒RNA基因组在原病毒DNA合成过程中发生环化。
Proc Natl Acad Sci U S A. 1976 Apr;73(4):1329-32. doi: 10.1073/pnas.73.4.1329.
2
In vitro transcription of theavian oncornavirus genome by the RNA-directed DNA polymerase: analysis of DNA transcripts synthesized in reconstructed enzymatic reactions.禽肿瘤病毒基因组由RNA指导的DNA聚合酶进行体外转录：对在重建酶促反应中合成的DNA转录本的分析
J Virol. 1977 Apr;22(1):86-96. doi: 10.1128/JVI.22.1.86-96.1977.
3
Initiation of DNA synthesis by the avian oncornavirus RNA-directed DNA polymerase: structural and functional localization of the major species of primer RNA on the oncornavirus genome.禽肿瘤病毒RNA指导的DNA聚合酶引发DNA合成：肿瘤病毒基因组上主要引物RNA种类的结构与功能定位
Virology. 1976 May;71(1):162-8. doi: 10.1016/0042-6822(76)90102-1.
4
Terminally repeated sequences in the avian sarcoma virus RNA genome.禽肉瘤病毒RNA基因组中的末端重复序列。
Proc Natl Acad Sci U S A. 1977 Jun;74(6):2389-93. doi: 10.1073/pnas.74.6.2389.
5
tRNATrp (bovine) binding to the reverse transcriptase of avian myeloblastosis virus and function as a heterologous primer.牛源色氨酸转运RNA（tRNATrp）与禽成髓细胞瘤病毒逆转录酶结合并作为异源引物发挥作用。
Proc Natl Acad Sci U S A. 1977 May;74(5):1889-93. doi: 10.1073/pnas.74.5.1889.
6
Specific binding of tryptophan transfer RNA to avian myeloblastosis virus RNA-dependent DNA polymerase (reverse transcriptase).色氨酸转移RNA与禽成髓细胞瘤病毒RNA依赖性DNA聚合酶（逆转录酶）的特异性结合。
Proc Natl Acad Sci U S A. 1975 Jul;72(7):2535-9. doi: 10.1073/pnas.72.7.2535.
7
Avian myeloblastosis reverse transcriptase deacylates tryptophanyl-tRNA.禽成髓细胞瘤逆转录酶使色氨酰 - tRNA脱酰基。
Nucleic Acids Res. 1982 Nov 25;10(22):7387-93. doi: 10.1093/nar/10.22.7387.
8
In vitro transcription of the avian retrovirus genome by the alpha form of the viral RNA-directed DNA polymerase.禽逆转录病毒基因组由病毒RNA指导的DNA聚合酶α形式进行的体外转录。
J Virol. 1977 Nov;24(2):704-8. doi: 10.1128/JVI.24.2.704-708.1977.
9
Enzymatic synthesis of duplex DNA by avian myeloblastosis viral reverse transcriptase.禽成髓细胞瘤病毒逆转录酶催化合成双链DNA
Gene Amplif Anal. 1981;2:1-16.
10
Formycin 3' end modified tRNATrp. Recognition by avian myeloblastosis virus reverse transcriptase and primer function.间型霉素3'末端修饰的色氨酸转运核糖核酸。禽成髓细胞瘤病毒逆转录酶的识别及引物功能。
Biochem Int. 1985 Jul;11(1):117-26.

引用本文的文献

1
At the nexus of science, engineering, and medicine: Pasteur's quadrant reconsidered.在科学、工程与医学的交叉点：重新审视巴斯德象限
PNAS Nexus. 2022 Jun 23;1(3):pgac092. doi: 10.1093/pnasnexus/pgac092. eCollection 2022 Jul.
2
Requirements for efficient minus strand strong-stop DNA transfer in human immunodeficiency virus 1.人免疫缺陷病毒 1 中有效负链强终止 DNA 转移的要求。
RNA Biol. 2011 Mar-Apr;8(2):230-6. doi: 10.4161/rna.8.2.14802. Epub 2011 Mar 1.
3
Circularization of the HIV-1 genome facilitates strand transfer during reverse transcription.HIV-1 基因组的环化有利于逆转录过程中的链转移。
RNA. 2010 Jun;16(6):1226-35. doi: 10.1261/rna.2039610. Epub 2010 Apr 29.
4
Viral DNA synthesized in vitro by avian retrovirus particles permeabilized with melittin. I. Kinetics of synthesis and size of minus- and plus-strand transcripts.蜂毒肽通透处理的禽逆转录病毒颗粒在体外合成的病毒DNA。I. 负链和正链转录本的合成动力学及大小
J Virol. 1981 Jan;37(1):109-16. doi: 10.1128/JVI.37.1.109-116.1981.
5
Molecular mechanism for the capture and excision of the transforming gene of avian sarcoma virus as suggested by analysis of recombinant clones.通过重组克隆分析提出的禽肉瘤病毒转化基因捕获与切除的分子机制
J Virol. 1980 Aug;35(2):436-43. doi: 10.1128/JVI.35.2.436-443.1980.
6
Structure of murine sarcoma virus DNA replicative intermediates synthesized in vitro.体外合成的鼠肉瘤病毒DNA复制中间体的结构
J Virol. 1980 Jan;33(1):377-89. doi: 10.1128/JVI.33.1.377-389.1980.
7
Equine infectious anemia virus and human immunodeficiency virus DNA synthesis in vitro: characterization of the endogenous reverse transcriptase reaction.马传染性贫血病毒和人类免疫缺陷病毒在体外的DNA合成：内源性逆转录酶反应的特征
J Virol. 1991 Apr;65(4):1952-9. doi: 10.1128/JVI.65.4.1952-1959.1991.
8
Partial reverse transcripts in virions from human immunodeficiency and murine leukemia viruses.来自人类免疫缺陷病毒和鼠白血病病毒的病毒粒子中的部分逆转录产物
J Virol. 1992 Aug;66(8):4893-900. doi: 10.1128/JVI.66.8.4893-4900.1992.
9
Cleavage map of linear mouse sarcoma virus DNA.线性小鼠肉瘤病毒DNA的切割图谱。
Proc Natl Acad Sci U S A. 1977 Jan;74(1):29-33. doi: 10.1073/pnas.74.1.29.
10
Effect of viral RNase H on the avian sarcoma viral genome during early transcription in vitro.病毒核糖核酸酶H在体外早期转录过程中对禽肉瘤病毒基因组的影响。
J Virol. 1979 Sep;31(3):630-8. doi: 10.1128/JVI.31.3.630-638.1979.

本文引用的文献

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RNA-directed DNA polymerase of Rous sarcoma virus: initiation of synthesis with 70 S viral RNA as template.劳氏肉瘤病毒的RNA指导DNA聚合酶：以70S病毒RNA为模板起始合成
J Mol Biol. 1973 Sep 5;79(1):163-83. doi: 10.1016/0022-2836(73)90277-5.
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RNA-directed DNA synthesis and RNA tumor viruses.RNA 指导的 DNA 合成与 RNA 肿瘤病毒
Adv Virus Res. 1972;17:129-86. doi: 10.1016/s0065-3527(08)60749-6.
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Purification and properties of bacteriophage T4-induced RNA ligase.噬菌体T4诱导的RNA连接酶的纯化及性质
Proc Natl Acad Sci U S A. 1972 Oct;69(10):3009-13. doi: 10.1073/pnas.69.10.3009.
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Virus-specific ribonucleic acid in cells producing rous sarcoma virus: detection and characterization.产生劳氏肉瘤病毒的细胞中的病毒特异性核糖核酸：检测与特性分析
J Virol. 1972 Jun;9(6):891-902. doi: 10.1128/JVI.9.6.891-902.1972.
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Purification and characterization of the deoxyribonucleic acid polymerase associated with Rous sarcoma virus.与劳氏肉瘤病毒相关的脱氧核糖核酸聚合酶的纯化与特性分析
Biochemistry. 1972 Jun 6;11(12):2334-42. doi: 10.1021/bi00762a020.
6
Deoxyribonucleic acid polymerase associated with Rous sarcoma virus and avian myeloblastosis virus: properties of the enzyme and its product.与劳氏肉瘤病毒和禽成髓细胞瘤病毒相关的脱氧核糖核酸聚合酶：酶及其产物的特性
J Virol. 1970 Nov;6(5):589-98. doi: 10.1128/JVI.6.5.589-598.1970.
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Tumor virus ribonucleic acid directed deoxyribonucleic acid synthesis: nucleotide sequence at the 5' terminus of nascent deoxyribonucleic acid.肿瘤病毒核糖核酸指导的脱氧核糖核酸合成：新生脱氧核糖核酸5'末端的核苷酸序列。
Biochemistry. 1974 Jul 16;13(15):3159-63. doi: 10.1021/bi00712a024.
8
Transcription of DNA from the 70S RNA of Rous sarcoma virus. II. Structure of a 4S RNA primer.劳斯肉瘤病毒70S RNA的DNA转录。II. 4S RNA引物的结构
J Virol. 1974 May;13(5):1134-42. doi: 10.1128/JVI.13.5.1134-1142.1974.
9
Transcription of DNA from the 70S RNA of Rous sarcoma virus. I. Identification of a specific 4S RNA which serves as primer.劳斯肉瘤病毒70S RNA的DNA转录。I. 作为引物的一种特定4S RNA的鉴定。
J Virol. 1974 May;13(5):1126-33. doi: 10.1128/JVI.13.5.1126-1133.1974.
10
Murine leukemia virus: detection of unintegrated double-stranded DNA forms of the provirus.鼠白血病病毒：前病毒未整合双链DNA形式的检测
Proc Natl Acad Sci U S A. 1975 Feb;72(2):447-51. doi: 10.1073/pnas.72.2.447.

通过体外逆转录研究获得的证据表明，禽肿瘤病毒RNA基因组在原病毒DNA合成过程中发生环化。

Evidence for circularization of the avian oncornavirus RNA genome during proviral DNA synthesis from studies of reverse transcription in vitro.

作者信息

Collett M S, Faras A J

出版信息

Proc Natl Acad Sci U S A. 1976 Apr;73(4):1329-32. doi: 10.1073/pnas.73.4.1329.

DOI:10.1073/pnas.73.4.1329
PMID:57620
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC430265/
Abstract

The RNA-directed DNA polymerase (deoxynucleosidetriphosphate:DNA deoxynucleotidyltransferase EC 2.7.7.7) of avian oncornavirus requires a tryptophan tRNA (tRNATrp) primer molecule located close to the 5' end of the viral RNA genome for the initiation of DNA synthesis in vitro. In this communication we demonstrate that the DNA product, transcribed from avian myeloblastosis virus (AMV) 35S RNA containing only tRNATrp as primer, is located also at the 5' end of the RNA genome. More importantly, we demonstrate that these 5' terminal DNA transcripts contain nucleotide sequences complementary to the 3' end of the genome. We have interpreted these results to mean that the genome. We have interpreted these results to mean that the 3' and 5' termini of the AMV 35S RNA genome become juxtaposed with each other either before or immediately after DNA synthesis has begun. These results are discussed in regard to the mechanism for synthesis of the circular forms of oncornavirus proviral DNA.

摘要

禽肿瘤病毒的RNA指导的DNA聚合酶（脱氧核苷三磷酸：DNA脱氧核苷酸转移酶，EC 2.7.7.7）在体外启动DNA合成时，需要一个位于病毒RNA基因组5'端附近的色氨酸tRNA（tRNATrp）引物分子。在本通讯中，我们证明，从仅含有tRNATrp作为引物的禽成髓细胞瘤病毒（AMV）35S RNA转录而来的DNA产物，也位于RNA基因组的5'端。更重要的是，我们证明这些5'末端DNA转录本含有与基因组3'端互补的核苷酸序列。我们对这些结果的解释是，AMV 35S RNA基因组的3'和5'末端在DNA合成开始之前或之后立即彼此并列。就肿瘤病毒前病毒DNA环状形式的合成机制对这些结果进行了讨论。