Hoshino Y, Wyatt R G, Greenberg H B, Kalica A R, Flores J, Kapikian A Z
Infect Immun. 1983 Jul;41(1):169-73. doi: 10.1128/iai.41.1.169-173.1983.
By the plaque reduction neutralization test, the CU-1 strain of canine rotavirus was similar, if not identical, to three strains (no. 14, no. 15, and P) of the tentatively designated third human rotavirus serotype. In addition, strain CU-1 demonstrated a one-way antigenic relationship with two other strains (M and B) of the third human rotavirus serotype. The CU-1 strain of canine rotavirus hemagglutinated human group O, rhesus monkey, dog, sheep, and guinea pig erythrocytes. A two-way antigenic relationship between canine (CU-1) and simian (MMU 18006 and SA11) rotaviruses demonstrated previously by the plaque reduction neutralization test was confirmed further with two additional isolates (A79-10 and LSU 79C-36) of canine rotavirus by the plaque reduction neutralization test and the hemagglutination inhibition test. The CU-1 strain of canine rotavirus, which is known to be distinct from two well-characterized human rotavirus serotypes (Wa and DS-1), was also found to be distinct from the St. Thomas no. 4 strain, which is a newly defined fourth human rotavirus serotype. Thus, this canine strain, which is related antigenically to one of four human rotavirus serotypes, is another example of an animal rotavirus which shares serotype specificity with a human rotavirus.
通过蚀斑减少中和试验，犬轮状病毒CU - 1株即便不是与暂定的第三种人轮状病毒血清型的三个毒株（14号、15号和P）完全相同，也是相似的。此外，CU - 1毒株与第三种人轮状病毒血清型的另外两个毒株（M和B）呈现单向抗原关系。犬轮状病毒CU - 1株能凝集人O型、恒河猴、犬、绵羊和豚鼠的红细胞。先前通过蚀斑减少中和试验证明的犬（CU - 1）和猴（MMU 18006和SA11）轮状病毒之间的双向抗原关系，通过蚀斑减少中和试验和血凝抑制试验，利用另外两株犬轮状病毒分离株（A79 - 10和LSU 79C - 36）进一步得到了证实。已知犬轮状病毒CU - 1株不同于两种特征明确的人轮状病毒血清型（Wa和DS - 1），还发现它也不同于新定义的第四种人轮状病毒血清型的圣托马斯4号毒株。因此，这种在抗原上与四种人轮状病毒血清型之一相关的犬毒株，是动物轮状病毒与人轮状病毒具有血清型特异性相同的又一个例子。
