Kempler D, Metter E J, Riege W H, Jackson C A, Benson D F, Hanson W R
School of Medicine, University of Southern California, Los Angeles.
J Neurol Neurosurg Psychiatry. 1990 Nov;53(11):987-93. doi: 10.1136/jnnp.53.11.987.
Three cases of slowly progressive speech and language disturbance were studied at various points post onset (three, five and 15 years respectively). Language, neuropsychological and brain imaging (computer tomography and positron emission tomography) evaluations were completed on all three patients. The data suggest that the syndrome of "progressive aphasia": 1) does not involve a uniform symptom complex; 2) does not necessarily develop into a full blown dementia syndrome; 3) varies greatly in rate of progression from case to case; 4) is associated with normal brain structure (on computer tomography); and 5) is associated with abnormal left temporal lobe metabolism as measured by fluorodeoxyglucose (FDG) positron emission tomography (PET). One patient had histological findings consistent with Alzheimer's disease at necropsy.
研究了3例起病后不同时间点（分别为起病后3年、5年和15年）缓慢进展的言语和语言障碍病例。对所有3例患者均完成了语言、神经心理学和脑成像（计算机断层扫描和正电子发射断层扫描）评估。数据表明，“进行性失语症”综合征：1）不涉及统一的症状组合；2）不一定发展为全面的痴呆综合征；3）病例之间进展速度差异很大；4）（计算机断层扫描显示）与正常脑结构相关；5）通过氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）测量，与左侧颞叶代谢异常相关。1例患者尸检时的组织学结果与阿尔茨海默病一致。
