Nazzaro-Porro M, Passi S, Picardo M, Breathnach A, Clayton R, Zina G
Br J Dermatol. 1983 Jul;109(1):45-8. doi: 10.1111/j.1365-2133.1983.tb03990.x.
Patients treated with azelaic acid (15%) cream for chloasma reported simultaneous improvement of acne lesions within the treated areas. This prompted an open study of its effect in cases of acne without chloasma. One hundred patients with acne vulgaris were treated for 3-9 months by twice-daily application of the cream with significant improvement in every case.
使用壬二酸（15%）乳膏治疗黄褐斑的患者报告称，治疗区域内的痤疮皮损同时有所改善。这促使人们对其在无黄褐斑痤疮病例中的效果进行了一项开放性研究。100例寻常痤疮患者每天两次涂抹该乳膏进行治疗，为期3至9个月，所有病例均有显著改善。
