用小颗粒气溶胶形式给予豚鼠感染伯纳特柯克斯体后细胞免疫和体液免疫的表现
Appearance of cellular and humoral immunity in guinea pigs after infection with Coxiella burnetii administered in small-particle aerosols.
作者信息
Kishimoto R A, Burger G T
出版信息
Infect Immun. 1977 May;16(2):518-21. doi: 10.1128/iai.16.2.518-521.1977.
Abstract
The development of humoral and cell-mediated immune responses was studied in guinea pigs infected with Coxiella burnetti administered in small-particle aerosols. Direct macrophage migration inhibition was observed in cultured peritoneal exudate cells as early as 3 days after exposure. Maximum inhibition of macrophages cultured with phase I or II antigen occurred 14 to 21 days postexposure and persisted through 35 days. This inhibitory action was no longer detectable at 42 days. Serum antibody to the phase II antigen of C. burnetii was detected at 14 days, and serum antibody to phase I antigen was detected at 21 days, 18 days after the cell-mediated immune response.
摘要
研究了豚鼠经小颗粒气溶胶感染伯纳特立克次体后体液免疫和细胞介导免疫反应的发展。早在暴露后3天，在培养的腹腔渗出细胞中就观察到直接巨噬细胞迁移抑制。用I期或II期抗原培养的巨噬细胞在暴露后14至21天出现最大抑制，并持续到35天。在42天时不再能检测到这种抑制作用。伯纳特立克次体II期抗原的血清抗体在14天时被检测到，I期抗原的血清抗体在21天时被检测到，即细胞介导免疫反应后18天。
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