类风湿关节炎患者血清中的抗胶原蛋白抗体。
Anti-collagen antibodies in sera from rheumatoid arthritis patients.
作者信息
Beard H K, Ryvar R, Skingle J, Greenbury C L
出版信息
J Clin Pathol. 1980 Nov;33(11):1077-81. doi: 10.1136/jcp.33.11.1077.
Abstract
Anti-cartilage antibodies, demonstrable by immunofluorescence, were found in 3.3% of rheumatoid arthritis patients. In most of these patients antibodies to type II collagen were detected. In specificity studies on these anti-collagen antibodies, they appeared to be type specific, showing no reaction with collagen types I and III. Denatured type II collagen reacted much less well than native type II, but isolated peptides from different regions of the collagen molecule were differentiated by individual sera. Removal of the glycoside side chains from native type II collagen had no effect on its antigenicity. The findings suggest that these patients produce highly specific antibodies which react with the triple helix of type II collagen.
摘要
通过免疫荧光可检测到的抗软骨抗体在3.3%的类风湿性关节炎患者中被发现。在这些患者中的大多数检测到了抗II型胶原抗体。在对这些抗胶原抗体的特异性研究中，它们似乎具有类型特异性，与I型和III型胶原无反应。变性II型胶原的反应性远低于天然II型胶原，但来自胶原分子不同区域的分离肽可被个体血清区分。从天然II型胶原中去除糖苷侧链对其抗原性没有影响。这些发现表明，这些患者产生了与II型胶原三螺旋反应的高度特异性抗体。
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本文引用的文献
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