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黑腹果蝇热休克激活基因的核苷酸序列。I. 杂交质粒56H8中hsp 70基因5'和3'末端区域的序列。

Nucleotide sequences of heat shock activated genes in Drosophila melanogaster. I. Sequences in the regions of the 5' and 3' ends of the hsp 70 gene in the hybrid plasmid 56H8.

作者信息

Török I, Karch F

出版信息

Nucleic Acids Res. 1980 Jul 25;8(14):3105-23. doi: 10.1093/nar/8.14.3105.

DOI:10.1093/nar/8.14.3105
PMID:6255408
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC324358/
Abstract

We present the sequences at the 5' and 3' ends of one hsp 70 gene variant which is derived from the chromosomal locus 87A7. The 5' end of the hsp 70 mRNA has also been determined. 550 bp upstream from the 5' end of the hsp 70 mRNA, there is a very A+T rich region shown by heteroduplex analysis to be also present at the same position in other hsp 70 genes9. The 5' end of the hsp 70 mRNA was found 26 bp after a characteristic "Hogness box". The first ATG codon was found 250 bp downstream from the 5' end of the hsp 70 mRNA. We also determined the termination codon at the 3' end of the hsp 70 gene. Comparisons with other genes are discussed.

摘要

我们展示了一个源自染色体位点87A7的热休克蛋白70（hsp 70）基因变体5'和3'端的序列。hsp 70信使核糖核酸（mRNA）的5'端也已确定。在hsp 70 mRNA 5'端上游550碱基对（bp）处，有一个富含腺嘌呤（A）和胸腺嘧啶（T）的区域，异源双链分析显示该区域在其他hsp 70基因的相同位置也存在。hsp 70 mRNA的5'端在一个特征性的“霍格内斯盒”后26 bp处被发现。第一个甲硫氨酸（ATG）密码子在hsp 70 mRNA 5'端下游250 bp处被发现。我们还确定了hsp 70基因3'端的终止密码子。文中讨论了与其他基因的比较。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ab4/324358/ffd6c8c30e83/nar00431-0055-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ab4/324358/474485e49e69/nar00431-0053-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ab4/324358/623675ce9551/nar00431-0054-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ab4/324358/ffd6c8c30e83/nar00431-0055-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ab4/324358/474485e49e69/nar00431-0053-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ab4/324358/623675ce9551/nar00431-0054-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ab4/324358/ffd6c8c30e83/nar00431-0055-a.jpg

相似文献

1
Nucleotide sequences of heat shock activated genes in Drosophila melanogaster. I. Sequences in the regions of the 5' and 3' ends of the hsp 70 gene in the hybrid plasmid 56H8.黑腹果蝇热休克激活基因的核苷酸序列。I. 杂交质粒56H8中hsp 70基因5'和3'末端区域的序列。
Nucleic Acids Res. 1980 Jul 25;8(14):3105-23. doi: 10.1093/nar/8.14.3105.
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Four heat shock proteins of Drosophila melanogaster coded within a 12-kilobase region in chromosome subdivision 67B.果蝇的四种热休克蛋白由位于第67B染色体亚区一个12千碱基区域内的基因编码。
Proc Natl Acad Sci U S A. 1980 Sep;77(9):5390-3. doi: 10.1073/pnas.77.9.5390.
3
DNA sequences flanking the starts of the hsp 70 and alpha beta heat shock genes are homologous.热休克蛋白70基因和αβ热休克基因起始位置两侧的DNA序列是同源的。
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Primary sequence of the 5' flanking regions of the Drosophila heat shock genes in chromosome subdivision 67B.果蝇67B染色体亚区热休克基因5'侧翼区域的一级序列。
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5
Sequence of three copies of the gene for the major Drosophila heat shock induced protein and their flanking regions.果蝇主要热休克诱导蛋白基因的三个拷贝序列及其侧翼区域。
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Two hybrid plasmids with D. melanogaster DNA sequences complementary to mRNA coding for the major heat shock protein.两个杂交质粒，其具有与编码主要热休克蛋白的mRNA互补的黑腹果蝇DNA序列。
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Genetic and molecular analysis of the 87A7 and 87C1 heat-inducible loci of D. melanogaster.黑腹果蝇87A7和87C1热诱导基因座的遗传与分子分析
Cell. 1979 Dec;18(4):1351-8. doi: 10.1016/0092-8674(79)90245-9.

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本文引用的文献

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Ubiquitous and gene-specific regulatory 5' sequences in a sea urchin histone DNA clone coding for histone protein variants.一个编码组蛋白变体的海胆组蛋白DNA克隆中普遍存在的和基因特异性的调控5'序列。
Nucleic Acids Res. 1980 Mar 11;8(5):957-77. doi: 10.1093/nar/8.5.957.
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Proc Natl Acad Sci U S A. 1980 Mar;77(3):1432-6. doi: 10.1073/pnas.77.3.1432.
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Two genes for the major heat-shock protein of Drosophila melanogaster arranged as an inverted repeat.
白斑综合征病毒附着于对虾信号转导和转录激活因子以增强立即早期基因ie1的表达。
J Virol. 2007 Feb;81(3):1461-71. doi: 10.1128/JVI.01880-06. Epub 2006 Nov 1.
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DNA sequence analysis reveals extensive homologies of regions preceding hsp70 and alphabeta heat shock genes in Drosophila melanogaster.DNA 序列分析揭示了果蝇 hsp70 和 alphabeta 热休克基因前区域的广泛同源性。
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6196-200. doi: 10.1073/pnas.78.10.6196.
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The baculovirus PE38 protein augments apoptosis induced by transactivator IE1.杆状病毒PE38蛋白增强反式激活因子IE1诱导的细胞凋亡。
J Virol. 1999 Aug;73(8):6691-9. doi: 10.1128/JVI.73.8.6691-6699.1999.
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Nineteen baculovirus open reading frames, including LEF-12, support late gene expression.包括LEF - 12在内的19个杆状病毒开放阅读框支持晚期基因表达。
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Role of baculovirus IE2 and its RING finger in cell cycle arrest.杆状病毒IE2及其环状结构域在细胞周期阻滞中的作用
J Virol. 1998 Jan;72(1):684-92. doi: 10.1128/JVI.72.1.684-692.1998.
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Doom, a product of the Drosophila mod(mdg4) gene, induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins.Doom是果蝇mod(mdg4)基因的产物，可诱导细胞凋亡并与杆状病毒凋亡抑制蛋白结合。
Mol Cell Biol. 1997 May;17(5):2835-43. doi: 10.1128/MCB.17.5.2835.
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Induction of apoptosis by baculovirus transactivator IE1.杆状病毒反式激活因子IE1诱导细胞凋亡
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10
In vivo transcriptional pausing and cap formation on three Drosophila heat shock genes.果蝇三个热休克基因的体内转录暂停和帽结构形成
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Nucleic Acids Res. 1980 Jan 25;8(2):235-52. doi: 10.1093/nar/8.2.235.
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The ovalbumin gene-sequence of putative control regions.假定调控区的卵清蛋白基因序列。
Nucleic Acids Res. 1980 Jan 11;8(1):127-42. doi: 10.1093/nar/8.1.127.
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Fragments produced by cleavage of lambda deoxyribonucleic acid with the Hemophilus parainfluenzae restriction enzyme Hpa II.用副流感嗜血杆菌限制性内切酶Hpa II切割λ脱氧核糖核酸产生的片段。
Biochemistry. 1973 Sep 25;12(20):3972-7. doi: 10.1021/bi00744a029.
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Protein synthesis in salivary glands of Drosophila melanogaster: relation to chromosome puffs.黑腹果蝇唾液腺中的蛋白质合成：与染色体疏松的关系。
J Mol Biol. 1974 Apr 15;84(3):389-98. doi: 10.1016/0022-2836(74)90447-1.
7
Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids.通过对S1核酸酶消化的杂交体进行凝胶电泳来确定早期腺病毒mRNA的大小并进行图谱分析。
Cell. 1977 Nov;12(3):721-32. doi: 10.1016/0092-8674(77)90272-0.
8
3' non-coding region sequences in eukaryotic messenger RNA.真核生物信使核糖核酸中的3'非编码区序列。
Nature. 1976 Sep 16;263(5574):211-4. doi: 10.1038/263211a0.
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A simple method for DNA restriction site mapping.一种用于DNA限制性酶切位点图谱绘制的简单方法。
Nucleic Acids Res. 1976 Sep;3(9):2387-98. doi: 10.1093/nar/3.9.2387.
10
Coincidence of the promoter and capped 5' terminus of RNA from the adenovirus 2 major late transcription unit.腺病毒2型主要晚期转录单元RNA的启动子与加帽5'末端的重合
Cell. 1978 Dec;15(4):1463-75. doi: 10.1016/0092-8674(78)90070-3.