果蝇主要热休克蛋白的两个基因以反向重复序列的形式排列。

Goldschmidt-Clermont M

Nucleic Acids Res. 1980 Jan 25;8(2):235-52. doi: 10.1093/nar/8.2.235.

The physical maps of three cloned D. melanogaster DNA fragments with genes for the 70,000 dalton heat-shock protein (hsp 70) are presented. Fragment 122 contains two genes in diverging orientation, forming an inverted repeat around a central spacer. The other two fragments, which are found as polymorphic variants in the fly population, have related structures; they differ by the deletion or the insertion of large DNA segments. The sequence homologies between 122 and a plasmid with two hsp 70 genes in tandem repetition was investigated by heteroduplex analysis. In addition to the basic gene units, the segments share other homologous sequence elements which are found in different combinations near the beginning of the genes.

本文展示了三个克隆的黑腹果蝇DNA片段的物理图谱，这些片段含有70,000道尔顿热休克蛋白（hsp 70）的基因。片段122包含两个方向相反的基因，围绕一个中央间隔区形成一个反向重复序列。另外两个片段在果蝇群体中以多态变体形式存在，具有相关结构；它们的区别在于大DNA片段的缺失或插入。通过异源双链分析研究了122与一个串联重复两个hsp 70基因的质粒之间的序列同源性。除了基本的基因单位外，这些片段还共享其他同源序列元件，这些元件在基因起始附近以不同组合形式存在。