Shaffer P T, Metcalf T G, Sproul O J
Appl Environ Microbiol. 1980 Dec;40(6):1115-21. doi: 10.1128/aem.40.6.1115-1121.1980.
Poliovirus 1 isolants were recovered from finished drinking water produced by a modern, well-operated water treatment plant. These waters contained free chlorine residuals in excess of 1 mg/liter. The chlorine inactivation of purified high-titer preparations of two such isolants was compared with the inactivation behavior of two stock strains of poliovirus 1, LSc and Mahoney. The surviving fraction of virus derived from the two natural isolants was shown to be orders of magnitude greater than that of the standard strains. These results raise the question whether indirect drinking water standards based on free chlorine residuals are adequate public health measures, or whether direct standards based on virus determinations might be necessary.
从一家现代化且运行良好的水处理厂生产的成品饮用水中分离出了脊髓灰质炎病毒1型毒株。这些水中的游离氯残留量超过1毫克/升。将两种此类毒株的纯化高滴度制剂的氯灭活情况与脊髓灰质炎病毒1型的两种标准毒株LSc和马奥尼的灭活行为进行了比较。结果表明，源自两种自然毒株的病毒存活比例比标准毒株的存活比例高出几个数量级。这些结果引发了一个问题，即基于游离氯残留量的间接饮用水标准是否是足够的公共卫生措施，或者基于病毒检测的直接标准是否可能是必要的。
