Ornstein M H, Littlewood E R, Baird I M, Fowler J, North W R, Cox A G
Br Med J (Clin Res Ed). 1981 Apr 25;282(6273):1353-6. doi: 10.1136/bmj.282.6273.1353.
Fifty-eight patients with uncomplicated diverticular disease of the colon took bran crispbread, ispaghula drink, and placebo for four months each in a randomised, cross-over, double-blind controlled trial. Assessments were made subjectively, using a monthly self-administered questionnaire, and objectively, by examining a seven-day stool collection at the end of each treatment period. In terms of a pain score, lower bowel symptom score (the pain score and sensation of incomplete emptying, straining, stool consistency, flatus, and aperients taken), and total symptom score (belching, nausea, vomiting, dyspepsia, and abdominal distension) fibre supplementation conferred no benefit. Symptoms of constipation, however, when assessed alone, were significantly relieved. Both fibre regimens produced the expected changes in stool weight, consistency, and frequency. It is concluded that dietary fibre supplements in the commonly used doses do no more than relieve constipation. Perhaps the impression that fibre helps diverticular disease is simply a manifestation of Western civilisation's obsession with the need for regular frequent defecation.
在一项随机、交叉、双盲对照试验中,58例患有单纯性结肠憩室病的患者分别服用麸皮脆饼、伊斯帕哈ula饮料和安慰剂,各为期4个月。评估采用主观方式,通过每月自行填写问卷进行,以及客观方式,在每个治疗期结束时检查7天的粪便收集情况。就疼痛评分、下消化道症状评分(疼痛评分以及排便未净感、用力排便、粪便稠度、肠胃气胀和缓泻剂服用情况)和总症状评分(嗳气、恶心、呕吐、消化不良和腹胀)而言,补充纤维并无益处。然而,单独评估便秘症状时,症状得到显著缓解。两种纤维疗法均使粪便重量、稠度和频率产生了预期变化。得出的结论是,常用剂量的膳食纤维补充剂仅能缓解便秘。或许认为纤维有助于治疗憩室病的印象仅仅是西方文明对定期频繁排便需求的一种痴迷表现。