Cummings J H, Jenkins D J, Wiggins H S
Gut. 1976 Mar;17(3):210-8. doi: 10.1136/gut.17.3.210.
A new method is described for measuring the mean transit time (MTT) of digesta through the human gut in which a constant amount of marker (radio-opaque pellets) is fed to subjects with each meal over a period of weeks, and its excretion measured in the stools. The MTT measured by this method (MTT-C) has been compared with MTT measured by giving single doses of similar markers to the same subjects (MTT-S) and with the 80% transit time (80% TT). Mean values on three dietary regimes for the MTT-C (54.2 h +/- 2.5) and MTT-S (54.2 +/- 2.6) were lower than that for 80% TT (63.1 +/- 3.0). The average MTT-C in a group of six healthy young men on an ad libitum diet was 2-3 days (range 0-7-4-0). When additional dietary fibre was added to a standard diet the average MTT-C fell (in all of five subjects) from 2-4 to 1-6 days. A continuous record of MTT-C is obtained by this new method which shows wide variations from week to week even on controlled dietary intakes. Using the single dose technique, evidence is produced which suggests that the MTT-S is a more accurate and reproducible method than the 80% TT.
本文描述了一种测量食糜在人体肠道内平均通过时间（MTT）的新方法。在数周时间内，每餐给受试者喂食恒定剂量的标记物（不透X线的药丸），并测量其在粪便中的排泄情况。通过该方法测得的MTT（MTT-C）已与给同一受试者单次服用类似标记物测得的MTT（MTT-S）以及80%通过时间（80% TT）进行了比较。三种饮食方案下MTT-C（54.2小时±2.5）和MTT-S（54.2±2.6）的平均值低于80% TT（63.1±3.0）。一组六名自由进食的健康年轻男性的平均MTT-C为2 - 3天（范围0 - 7 - 4 - 0）。当在标准饮食中添加额外膳食纤维时，平均MTT-C（所有五名受试者）从2 - 4天降至1 - 6天。通过这种新方法可获得MTT-C的连续记录，结果显示即使在控制饮食摄入的情况下，每周之间也存在很大差异。使用单剂量技术得出的证据表明，MTT-S比80% TT是一种更准确且可重复的方法。
