[Morphogenesis of human rotavirus in a cell culture].

Morphogenesis of human rotavirus was studied by primary green monkey kidney cell culture by electron microscopy, at the levels of the 5th and 12th passage in the cell culture. The initial stages of rotavirus morphogenesis were shown to be associated with cytoplasmic inclusions. Nucleoid or core particles formed in the periphery of the inclusions were transported by budding to endoplasmic reticulum cavities where the final stages of virion maturation occurred. The loss of the outer membrane seems to be a component part of this process. Increasing number of virus passages in the cell culture exerted a certain effect on morphogenetic processes in the infected cells.