整合型猿猴肉瘤病毒长末端重复序列的核苷酸序列分析：与其他哺乳动物逆转录病毒长末端重复序列的进化关系。
Nucleotide sequence analysis of the long terminal repeat of integrated simian sarcoma virus: evolutionary relationship with other mammalian retroviral long terminal repeats.
作者信息
Devare S G, Reddy E P, Law J D, Aaronson S A
出版信息
J Virol. 1982 Jun;42(3):1108-13. doi: 10.1128/JVI.42.3.1108-1113.1982.
Abstract
Nucleotide sequence analysis of the long terminal repeat (LTR) of the integrated simian sarcoma virus showed that the simian sarcoma virus LTR comprised 504 nucleotides with an inverted repeat of seven bases at its 5' and 3' termini. At the site of simian sarcoma virus integration, cellular flanking sequences adjacent to the proviral LTR contained a direct repeat of four bases. A 13-base sequence after the 5' LTR was found to be complementary to prolyl tRNA, suggesting that tRNAPro may serve as the primer for reverse transcription of simian sarcoma virus RNA. The U5 and R regions, derived respectively from the 5' end and terminally redundant sequences of the viral RNA, were found to have similar organization and sequence homology close to that of Moloney murine sarcoma virus or Moloney murine leukemia virus. These results indicate that regions within LTRs with known functionally important sequences have been most well conserved during retrovirus evolution.
摘要
对整合的猿猴肉瘤病毒长末端重复序列（LTR）进行的核苷酸序列分析表明，猿猴肉瘤病毒LTR由504个核苷酸组成，在其5'和3'末端有一个7个碱基的反向重复序列。在猿猴肉瘤病毒整合位点，与前病毒LTR相邻的细胞侧翼序列包含一个4个碱基的正向重复序列。在5' LTR之后发现一个13个碱基的序列与脯氨酰tRNA互补，这表明tRNAPro可能作为猿猴肉瘤病毒RNA逆转录的引物。分别来自病毒RNA 5'端和末端冗余序列的U5和R区域，其组织和序列同源性与莫洛尼氏鼠肉瘤病毒或莫洛尼氏鼠白血病病毒相似。这些结果表明，在逆转录病毒进化过程中，LTR内具有已知功能重要序列的区域保存最为完好。
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