Galland F, Geslin P, Kerjean J, Six P, Tadeï A, Jallet P
Sem Hop. 1982 Mar 18;58(11):665-70.
This work undertakes, in a second part, the clinical exploration of 947 serum digoxin levels of 281 hospitalized patients on a cardiology ward. Our results which coincide with those of other researchers, have led us to draw certain practical conclusions: the posology is determined first of all according to kidney function, weight and age of the patient. When the treatment is insufficient or on the other hand, poorly tolerated, a serum digoxin level is performed permitting thus: 1) in the case of ineffective treatment: to be sure of the patient's cooperation, to increase the posology if the serum digoxin level is not in the toxic zone, to discover an eventual pharmacokinetic problem; 2) to establish the responsibility of digitalis (when there are signs of intolerance or of intoxication), in case of arrhythmia, in patients with pacemakers, when associated drugs are capable of causing similar adverse effects; 3) to better manage a digitalis treatment in a high risk patient (unstable renal function, advanced myocardial disease, chronic obstructive disease).
在第二部分中，这项研究对心脏病病房281名住院患者的947份血清地高辛水平进行了临床探究。我们的结果与其他研究人员的结果一致，这使我们得出了某些实际结论：首先根据患者的肾功能、体重和年龄来确定用药剂量。当治疗不足或耐受性差时，检测血清地高辛水平可带来如下帮助：1）在治疗无效的情况下：确保患者的配合，若血清地高辛水平不在中毒范围内则增加用药剂量，发现可能存在的药代动力学问题；2）确定洋地黄的责任（当出现不耐受或中毒迹象时），在心律失常的情况下，对于有起搏器的患者，当联合使用的药物可能导致类似不良反应时；3）更好地管理高危患者（肾功能不稳定、晚期心肌病、慢性阻塞性疾病）的洋地黄治疗。
