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大肠杆菌溶血素的遗传学及致病作用

Genetics and pathogenic role of Escherichia coli haemolysin.

作者信息

Hughes C, Müller D, Hacker J, Goebel W

出版信息

Toxicon. 1982;20(1):247-52. doi: 10.1016/0041-0101(82)90210-0.

DOI:10.1016/0041-0101(82)90210-0
PMID:6281939
Abstract

While clear evidence exists for the direct involvement of cytolysins in the pathogenesis of Gram-positive bacteria, the significance of Gram-negative haemolysins remains unclear. This paper presents briefly data indicating a role for haemolysin production in infections caused by Escherichia coli and also experiments which have allowed an analysis of the molecular basis of the haemolysis among pathogenic and non-pathogenic strains of this species.

摘要

虽然有明确证据表明溶细胞素直接参与革兰氏阳性菌的发病机制,但革兰氏阴性溶血素的重要性仍不清楚。本文简要介绍了表明溶血素产生在大肠杆菌引起的感染中所起作用的数据,以及对该物种致病和非致病菌株溶血分子基础进行分析的实验。

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Genetics and pathogenic role of Escherichia coli haemolysin.大肠杆菌溶血素的遗传学及致病作用
Toxicon. 1982;20(1):247-52. doi: 10.1016/0041-0101(82)90210-0.
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[Virulence factors in strains of Escherichia coli isolated in urinary tract infections].[尿路感染中分离出的大肠杆菌菌株的毒力因子]
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Serum resistance of Escherichia coli strains causing urinary tract infection and diarrhoea in relation to alpha haemolysin production and O type.引起尿路感染和腹泻的大肠杆菌菌株的血清抗性与α溶血素产生及O型的关系
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Characterization of Escherichia coli strains isolated from urine of secretors and non-secretors.从分泌型和非分泌型人群尿液中分离出的大肠杆菌菌株的特征分析。
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Antibiotic resistance, haemagglutination type & haemolysin production in relation to serogroups of uropathogenic Escherichia coli.与尿路致病性大肠杆菌血清群相关的抗生素耐药性、血凝类型及溶血素产生情况
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Haemolysin and necrotoxin production of Escherichia coli with special reference to serotypes causing urinary tract infections.大肠杆菌溶血素和坏死毒素的产生,特别涉及引起尿路感染的血清型。
Indian J Pathol Microbiol. 1981 Jan;24(1):33-8.

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Cloned hemolysin genes from Escherichia coli that cause urinary tract infection determine different levels of toxicity in mice.从导致尿路感染的大肠杆菌中克隆出的溶血素基因在小鼠体内表现出不同程度的毒性。
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