Wang C Y, Kamiryo Y, Croft W A
Carcinogenesis. 1982;3(3):275-7. doi: 10.1093/carcin/3.3.275.
Female Fischer rats were divided into two groups and fed either basal diet or basal diet containing 0.166% 2-amino-4-(5-nitro-2-furyl) thiazole for 52 weeks followed by basal diet for an additional 16 weeks. Our of the 24 rats fed 2-amino-4-(5-nitro-2-furyl) thiazole, 23 had forestomach tumors, four had fibroadenomas and two had adenocarcinomas in the mammary glands, two had renal pelvic carcinomas, five had papillomas and six had carcinomas in the bladder, and two had cutaneous tumors. None of the 10 rats fed basal diet developed tumors. In another study, two-week-old Fischer rats of both sexes were injected s.c. once a week for the first eight weeks with 2-amino-4-(5-nitro-2-furyl) thiazole at a dose of 10 mg/kg and then 1.4 mg/rat for an additional 46 weeks. The control rats were injected with solvent (dimethyl sulfoxide: water, 1:1) only. The experiment was terminated at the end of 58 weeks. Malignant fibrous histiocytomas were found in five out of eight male rats and four out of 11 female rats, and an angiosarcoma was found in one out of eight male rats injected with 2-amino-4-(5-nitro-2-furyl) thiazole. None of the control rats developed tumors.
将雌性Fischer大鼠分为两组，分别喂食基础饲料或含有0.166% 2-氨基-4-(5-硝基-2-呋喃基)噻唑的基础饲料，持续52周，之后再喂食基础饲料16周。在喂食2-氨基-4-(5-硝基-2-呋喃基)噻唑的24只大鼠中，23只发生了前胃肿瘤，4只发生了乳腺纤维腺瘤，2只发生了乳腺腺癌，2只发生了肾盂癌，5只发生了膀胱乳头状瘤，6只发生了膀胱癌，2只发生了皮肤肿瘤。喂食基础饲料的10只大鼠均未发生肿瘤。在另一项研究中，两周龄的雌雄Fischer大鼠在最初八周每周皮下注射一次剂量为10 mg/kg的2-氨基-4-(5-硝基-2-呋喃基)噻唑，之后46周每周注射1.4 mg/只。对照大鼠仅注射溶剂（二甲亚砜：水，1:1）。实验在58周结束时终止。在注射2-氨基-4-(5-硝基-2-呋喃基)噻唑的8只雄性大鼠中有5只、11只雌性大鼠中有4只发生了恶性纤维组织细胞瘤，在8只雄性大鼠中有1只发生了血管肉瘤。对照大鼠均未发生肿瘤。
