galR基因序列表明大肠杆菌中乳糖阻遏蛋白和半乳糖阻遏蛋白有共同的进化起源。
Sequence of galR gene indicates a common evolutionary origin of lac and gal repressor in Escherichia coli.
作者信息
von Wilcken-Bergmann B, Müller-Hill B
出版信息
Proc Natl Acad Sci U S A. 1982 Apr;79(8):2427-31. doi: 10.1073/pnas.79.8.2427.
Abstract
The nucleotide sequence of the galR gene of Escherichia coli, which codes for galactose repressor, has been determined. The subunits of gal repressor are predicted to consist of 343 residues, including the NH2-terminal methionine. Twenty-six of the predicted NH2-terminal 55 residues of gal repressor are identical to the NH2-terminal residues of lac repressor. Additional homologies appear between residues 165 and 200, between residues 235 and 255, and around residue 325.
摘要
已确定编码半乳糖阻遏物的大肠杆菌galR基因的核苷酸序列。预计半乳糖阻遏物的亚基由343个残基组成，包括氨基末端的甲硫氨酸。预测的半乳糖阻遏物氨基末端55个残基中的26个与乳糖阻遏物的氨基末端残基相同。在残基165和200之间、残基235和255之间以及残基325附近还出现了其他同源性。
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