Br Med J (Clin Res Ed). 1982 Jul 31;285(6338):357-9. doi: 10.1136/bmj.285.6338.357.
A national assessment of the efficacy of pertussis vaccination was made in 21 area health authorities in England. Notification rates for children given either three doses of diphtheria/tetanus/pertussis vaccine or diphtheria/tetanus vaccine were studied during the two and a half-year period January 1978-June 1980. A survey of home circumstances showed that the two vaccine groups could be validly compared. Home visits were made to assess the severity of the illness, the attack rates in home contacts, and to take pernasal swabs. Pertussis vaccination was found to be of outstanding value in preventing serious disease. Nevertheless, its effect in controlling whooping cough is limited by the fact that protection for home contacts is less satisfactory, and by the occurrence of mild cases in vaccinated children which may contribute to the spread of the disease.
在英国的21个地区卫生当局对百日咳疫苗接种的效果进行了全国性评估。在1978年1月至1980年6月的两年半时间里，对接种三剂白喉/破伤风/百日咳疫苗或白喉/破伤风疫苗的儿童的报告率进行了研究。一项家庭情况调查表明，这两个疫苗组可以进行有效比较。进行了家访，以评估疾病的严重程度、家庭接触者的发病率，并采集鼻咽拭子。发现百日咳疫苗接种在预防严重疾病方面具有突出价值。然而，其在控制百日咳方面的效果受到以下因素的限制：对家庭接触者的保护不太令人满意，以及接种疫苗的儿童中出现轻症病例，这可能会导致疾病传播。
