Vesselinova-Jenkins C K, Newcombe R G, Gray O P, Skone J F, Howells C H, Lennox M, Hine D J, Jenkins P M, Munro J A
J Epidemiol Community Health (1978). 1978 Sep;32(3):194-9. doi: 10.1136/jech.32.3.194.
During an outbreak of pertussis in the Cardiff area in 1974, 229 children with the disease were studied to assess the effect of immunisation upon its natural history and severity. The typical clinical features of pertussis, such as paroxysmal cough, whooping, vomiting, cyanosis, and irregular breathing, were less prevalent in both the immunised and the older children. Immunisation is the main factor in protecting against complications such as fits; and, together with older age, it protects against hospitalisation. Nevertheless, pertussis today can be just as severe as it was 40 years ago, and the vaccine remains the major factor ameliorating its natural history. The immunisation programme needs more active support by all child health workers.
1974年加的夫地区爆发百日咳期间，对229名患该病的儿童进行了研究，以评估免疫接种对其自然病程和严重程度的影响。百日咳的典型临床特征，如阵发性咳嗽、哮吼、呕吐、发绀和呼吸不规则，在接种过疫苗的儿童和年龄较大的儿童中都不太常见。免疫接种是预防诸如惊厥等并发症的主要因素；并且，与年龄较大一起，它还能预防住院。然而，如今百日咳的严重程度仍可能与40年前一样，而疫苗仍然是改善其自然病程的主要因素。免疫接种计划需要所有儿童保健工作者给予更积极的支持。
