Rastkar G, Okagaki T, Twiggs L B, Clark B A
Am J Obstet Gynecol. 1982 Aug 1;143(7):814-20. doi: 10.1016/0002-9378(82)90015-1.
Cases of carcinoma of the vulva with a warty appearance were reviewed. Altogether, 27 cases of warty carcinoma of the vulva were treated at the University of Minnesota Hospitals between 1976 and 1980, which accounted for 22.4% of all vulvar epithelial malignancies. As compared to the previous experience between 1951 and 1970, this relative frequency increased fourfold. Clinical history indicated that warty carcinoma of the vulva was not necessarily preceded by long lead periods of in situ lesions. The lesions seemed to occur in all ages after adolescence, were multifocal in one third of the cases, were frequently locally recurring, and were relatively benign despite their often large size. Many of them were originally diagnosed as condyloma acuminatum. Virus-like particles were seen in eight of the 12 cases (67%) examined with transmission electron microscopy, which included six cases of invasive lesions. These observations suggest that human papillomavirus (HPV) may be the important etiologic agent of this group of tumors. Warty carcinoma of the vulva must be clearly separated from conventional invasive squamous cell carcinoma of the vulva, as its clinical behavior and a possible etiology appear unique.
对外观呈疣状的外阴癌病例进行了回顾。1976年至1980年间，明尼苏达大学医院共治疗了27例外阴疣状癌，占所有外阴上皮恶性肿瘤的22.4%。与1951年至1970年的既往经验相比，这一相对频率增加了四倍。临床病史表明，外阴疣状癌不一定有很长的原位病变前期。这些病变似乎在青春期后的所有年龄段都有发生，三分之一的病例为多灶性，经常局部复发，尽管通常体积较大，但相对良性。其中许多最初被诊断为尖锐湿疣。在12例经透射电子显微镜检查的病例中，有8例（67%）可见病毒样颗粒，其中包括6例浸润性病变。这些观察结果提示，人乳头瘤病毒（HPV）可能是这组肿瘤的重要病因。外阴疣状癌必须与传统的外阴浸润性鳞状细胞癌明确区分，因为其临床行为和可能的病因似乎具有独特性。
