Kono Y, Sentsui H, Miyamoto T, Morozumi K, Sakamoto Y
Int J Cancer. 1982 Nov 15;30(5):655-7. doi: 10.1002/ijc.2910300517.
Changes in titers of antibodies to protein and glycoprotein antigens of bovine leukemia virus (BLV) were investigated by immunodiffusion in two groups of cattle. In one group of cattle (10 head) which developed enzootic bovine leukosis during the observation period of 3 years, seven showed a gradual increase in antibody titers following a period of level antibody titers that persisted for several months to several years. The titer was finally eight to 32 times higher than the initial titer. The remaining three showed little change in titer. Of the 10 animals with tumors, three showed a decrease in the titer when they were in extremis. In contrast, in the second group of cattle (110 head), which were infected with BLV subclinically, the change in the titers during 1 and 3 years ranged from no change to four times the lowest titer that was observed during the period. Of the cattle which had a low level of antibody to one of the BLV antigens, a few became negative reactors to the respective antigen.
通过免疫扩散法对两组牛体内抗牛白血病病毒（BLV）蛋白质和糖蛋白抗原的抗体滴度变化进行了研究。在一组牛（10头）中，这些牛在3年的观察期内发生了地方流行性牛白血病，其中7头牛在抗体滴度维持数月至数年的稳定期后，抗体滴度逐渐升高。最终滴度比初始滴度高8至32倍。其余3头牛的滴度几乎没有变化。在10头患有肿瘤的动物中，有3头在濒死时滴度下降。相比之下，在第二组牛（110头）中，这些牛受到BLV亚临床感染，1年和3年期间滴度变化范围从无变化到观察期内最低滴度的4倍。在对其中一种BLV抗原抗体水平较低的牛中，有几头对相应抗原变为阴性反应。
