Orengo I F, Black H S, Wolf J E
Department of Dermatology, Baylor College of Medicine Houston, Tex.
Arch Dermatol Res. 1992;284(4):219-21. doi: 10.1007/BF00375797.
A previous study using the hairless mouse model demonstrated that diets containing a fish-oil lipid source, which contained high levels of omega-3 fatty acids, markedly increased the minimum erythema dose (MED) when compared with diets containing other polyunsaturated fatty acids. To determine whether fish oil supplementation could produce a similar effect in humans, 20 subjects were randomized into two groups, a placebo group and a group receiving fish-oil supplements over a 4-week period. Results showed a small, but statistically significant, increase in MED in patients whose diet was supplemented with fish oil. Cholesterol and prostaglandin E2 levels were unchanged, while triglyceride levels were significantly decreased in the fish oil group. No significant changes in any of these parameters occurred in the placebo group.
此前一项使用无毛小鼠模型的研究表明，与含有其他多不饱和脂肪酸的饮食相比，含有高水平ω-3脂肪酸的鱼油脂质源饮食显著增加了最小红斑量（MED）。为了确定补充鱼油是否能在人类中产生类似效果，20名受试者被随机分为两组，一组为安慰剂组，另一组在4周内接受鱼油补充剂。结果显示，饮食中补充鱼油的患者MED有小幅但具有统计学意义的增加。胆固醇和前列腺素E2水平没有变化，而鱼油组的甘油三酯水平显著降低。安慰剂组这些参数均无显著变化。
