Studdert M J, Oda C, Riegl C A, Roston R P
Aust Vet J. 1983 Jul;60(7):197-200. doi: 10.1111/j.1751-0813.1983.tb09581.x.
Between 18 July 1980 and 2 January 1981, 188 samples (145 faeces and 43 intestinal contents) were submitted from dogs with suspected canine parvovirus (CPV) enteritis. CPV was demonstrated in 56 (30%) of these samples; the weekly rate of positive CPV identification was remarkably constant at approximately 30% even though clinical and often post-mortem findings strongly supported a diagnosis of CPV enteritis. The simplest, most sensitive and most rapid method for detection of virus was haemagglutination (HA) which was twice as sensitive as isolation of virus and 8 times as sensitive as electron microscopy (EM). Forty nine of 56 (88%) samples positive for CPV were from dogs less than 1 year old and 44 (79%) CPV-positive samples were from pups less than 6 months old; only one sample from a pup less than 2 months old (pup was 7 weeks old) was positive. An additional 68 samples (53 faeces and 15 intestinal contents) were submitted from Beagle dogs that were part of a colony of approximately 1200 dogs. Epidemiological data pinpoints the entry of CPV into the colony in November 1978 at which time most dogs including pups less than 6 months of age developed antibody to CPV without developing clinical disease. From these data an overview of some aspects of the pathogenesis and epidemiology of CPV is constructed.
在1980年7月18日至1981年1月2日期间，从疑似患有犬细小病毒（CPV）肠炎的犬只中提交了188份样本（145份粪便和43份肠内容物）。在这些样本中，有56份（30%）检测出CPV；尽管临床及常有的尸检结果强烈支持CPV肠炎的诊断，但CPV阳性鉴定的周率仍显著稳定在约30%。检测病毒最简单、最灵敏且最快速的方法是血凝试验（HA），其灵敏度是病毒分离法的两倍，是电子显微镜检查（EM）的8倍。56份CPV阳性样本中有49份（88%）来自1岁以下的犬只，44份（79%）CPV阳性样本来自6个月以下的幼犬；只有一份来自2个月以下幼犬（幼犬7周龄）的样本呈阳性。另外68份样本（53份粪便和15份肠内容物）来自大约1200只犬的群体中的比格犬。流行病学数据确定CPV于1978年11月进入该群体，当时包括6个月以下幼犬在内的大多数犬只产生了针对CPV的抗体，但未出现临床疾病。根据这些数据构建了CPV发病机制和流行病学某些方面的概述。
