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泰国的人类白细胞抗原(HLA)抗原、基因及单倍型频率

HLA antigen, gene, and haplotype frequencies in Thailand.

作者信息

Greiner J, Schleiermacher E, Lenhard V, Kulapongs P, Vogel F

出版信息

Hum Genet. 1978 Feb 23;41(1):73-87. doi: 10.1007/BF00278873.

Abstract

Antigen, gene, and haplotype frequencies as well as phenotype distribution of the HLA system were studied in a series of 213 individuals in northern Thailand. The series consisted of 160 northern Thais, 23 Thai individuals from various other regions of Thailand, and 25 persons of Chinese origin. Most frequently found were the alleles HLA-A11 and HLA-Bw40 and the haplotype HLA-A2,B-. Phenotype distribution followed a Hardy-Weinberg expectation. Significant differences were found especially between our results for the alleles of locus B and the results of a series from Bangkok reported by Chiewsilp and Chanarat (1976).

摘要

在泰国北部的213名个体中研究了HLA系统的抗原、基因和单倍型频率以及表型分布。该系列包括160名泰国北部人、23名来自泰国其他不同地区的泰国人以及25名华裔。最常见的等位基因是HLA - A11和HLA - Bw40,单倍型是HLA - A2,B -。表型分布符合哈迪-温伯格预期。尤其在我们关于B位点等位基因的结果与Chiewsilp和Chanarat(1976年)报道的曼谷一组研究结果之间发现了显著差异。

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