Jorfeldt L, Juhlin-Dannfelt A, Karlsson J
J Appl Physiol Respir Environ Exerc Physiol. 1978 Mar;44(3):350-2. doi: 10.1152/jappl.1978.44.3.350.
In four healthy volunteers, muscle lactate concentration and the release of lactate from the leg were determined at rest and at 4 and 12 min of sitting bicycle exercise at four intensities (30, 50, 70, and 90% of maximal oxygen uptake). The muscle biopsies were obtained by needle biopsy technique from m. vastus lateralis. The rate of lactate release was calculated from the femoral venous-arterial differences of lactate and the leg blood flow was determined by constant rate dye infusion. Both leg blood flow and leg oxygen consumption increased linearly with work intensity. The release of lactate rose approximately linearly with the muscle lactate concentration up to about 4-5 mmol/min but then the relationship revealed a clear leveling off. These results indicate a maximal level for the lactate release from the exercising muscles with a translocation hindrance for lactate within the muscles.
在四名健康志愿者中，于静息状态以及在以四种强度（最大摄氧量的30%、50%、70%和90%）进行坐姿自行车运动4分钟和12分钟时，测定了肌肉乳酸浓度以及腿部乳酸的释放量。通过针吸活检技术从股外侧肌获取肌肉活检样本。乳酸释放速率根据股静脉 - 动脉乳酸差值计算得出，腿部血流量通过恒速染料注入法测定。腿部血流量和腿部耗氧量均随工作强度呈线性增加。乳酸释放量随肌肉乳酸浓度升高大致呈线性增加，直至约4 - 5 mmol/min，但随后这种关系明显趋于平稳。这些结果表明，运动肌肉的乳酸释放存在一个最大值，且肌肉内乳酸转运存在阻碍。
