Pollock T M, Miller E, Lobb J
Arch Dis Child. 1984 Feb;59(2):162-5. doi: 10.1136/adc.59.2.162.
Since the decline of pertussis immunisation, hospital admission and death rates from whooping cough have fallen unexpectedly. Although this might be taken to indicate that the disease is becoming less severe, a comparison of admissions and deaths in England and Wales before and after the decline in immunisation suggests that several factors other than disease severity--a shift in the social class distribution of the disease, an increase in the proportion of milder cases notified, and improved care--were responsible for this. The severity of attacks and the complication rates in children admitted to hospital were virtually unchanged. Very young infants, those from disadvantaged families, and children with chronic illness were at greatest risk.
自从百日咳免疫接种率下降以来，百日咳导致的住院率和死亡率意外下降。尽管这可能被视为表明该疾病正变得不那么严重，但对英格兰和威尔士免疫接种率下降前后的住院和死亡情况进行比较后发现，除疾病严重程度外的其他几个因素——疾病社会阶层分布的变化、报告的轻症病例比例增加以及护理改善——是造成这种情况的原因。住院儿童的发作严重程度和并发症发生率实际上没有变化。非常小的婴儿、来自弱势家庭的婴儿以及患有慢性病的儿童风险最大。
