Langsley G, Hyde J E, Goman M, Scaife J G
Nucleic Acids Res. 1983 Dec 20;11(24):8703-17. doi: 10.1093/nar/11.24.8703.
Ribosomal DNA fragments from the human malaria parasite Plasmodium falciparum have been cloned and analysed in detail. Restriction mapping shows that the cloned fragments are different. However, they do have some similarities, in particular a small stretch of A+T-rich DNA located between the small and large subunit rRNA genes. A small rRNA gene has been mapped to this A+T-rich region. Copy number analysis reveals that each fragment is represented approximately 4 times in the genome, and implies that there are a total of 8 rRNA genes organised into at least two classes of transcription unit. Analysis of a third overlapping rDNA fragment indicates that the large subunit rRNA gene of at least one transcription unit contains an intervening sequence.
来自人类疟原虫恶性疟原虫的核糖体DNA片段已被克隆并进行了详细分析。限制性图谱分析表明，克隆的片段各不相同。然而，它们确实有一些相似之处，特别是在小亚基和大亚基rRNA基因之间存在一小段富含A+T的DNA。一个小rRNA基因已被定位到这个富含A+T的区域。拷贝数分析表明，每个片段在基因组中大约有4个拷贝，这意味着总共有8个rRNA基因，它们被组织成至少两类转录单元。对第三个重叠rDNA片段的分析表明，至少一个转录单元的大亚基rRNA基因含有一个间隔序列。
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