从酿酒酵母中分离出的两个与rasH相关基因的核苷酸序列。
Nucleotide sequence of two rasH related-genes isolated from the yeast Saccharomyces cerevisiae.
作者信息
Dhar R, Nieto A, Koller R, DeFeo-Jones D, Scolnick E M
出版信息
Nucleic Acids Res. 1984 Apr 25;12(8):3611-8. doi: 10.1093/nar/12.8.3611.
Abstract
A complete nucleotide sequence of two ras-related yeast genes (c- rassc -1 and c- rassc -2) isolated from the yeast strain Saccharomyces cerevisiae is reported. They encode predicted polypeptides of 40,000 and 41,000 daltons, respectively. The N-terminal 170 amino acids from both genes show extensive amino acid homology to other ras genes from vertebrates, whereas their C-termini have diverged. These genes should be useful in the elucidation of a normal biological function of ras-related genes in a simple system like yeast.
摘要
报道了从酿酒酵母菌株中分离出的两个与ras相关的酵母基因（c-rassc-1和c-rassc-2）的完整核苷酸序列。它们分别编码预测分子量为40,000和41,000道尔顿的多肽。这两个基因的N端170个氨基酸与脊椎动物的其他ras基因显示出广泛的氨基酸同源性，而它们的C端则有所不同。这些基因将有助于在酵母这样的简单系统中阐明与ras相关基因的正常生物学功能。
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