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本文引用的文献

1
The primary and secondary structure of yeast 26S rRNA.酵母26S核糖体RNA的一级和二级结构。
Nucleic Acids Res. 1981 Dec 21;9(24):6935-52. doi: 10.1093/nar/9.24.6935.
2
The site of action of alpha-sarcin on eukaryotic ribosomes. The sequence at the alpha-sarcin cleavage site in 28 S ribosomal ribonucleic acid.α-肌动蛋白对真核生物核糖体的作用位点。28S核糖体核糖核酸中α-肌动蛋白切割位点的序列。
J Biol Chem. 1982 Aug 10;257(15):9054-60.
3
Secondary structure model for 23S ribosomal RNA.23S核糖体RNA的二级结构模型
Nucleic Acids Res. 1981 Nov 25;9(22):6167-89. doi: 10.1093/nar/9.22.6167.
4
Secondary structure of the large subunit ribosomal RNA from Escherichia coli, Zea mays chloroplast, and human and mouse mitochondrial ribosomes.来自大肠杆菌、玉米叶绿体以及人类和小鼠线粒体核糖体的大亚基核糖体RNA的二级结构。
Nucleic Acids Res. 1981 Jul 24;9(14):3287-306. doi: 10.1093/nar/9.14.3287.
5
The structure of the yeast ribosomal RNA genes. 4. Complete sequence of the 25 S rRNA gene from Saccharomyces cerevisae.酵母核糖体RNA基因的结构。4. 酿酒酵母25 S rRNA基因的完整序列。
Nucleic Acids Res. 1981 Dec 21;9(24):6953-8. doi: 10.1093/nar/9.24.6953.
6
Refined secondary structure models for the 16S and 23S ribosomal RNA of Escherichia coli.大肠杆菌16S和23S核糖体RNA的精细二级结构模型
Nucleic Acids Res. 1983 Nov 11;11(21):7263-86. doi: 10.1093/nar/11.21.7263.
7
The structure of rat 28S ribosomal ribonucleic acid inferred from the sequence of nucleotides in a gene.从一个基因中的核苷酸序列推断出的大鼠28S核糖体核糖核酸的结构。
Nucleic Acids Res. 1983 Nov 25;11(22):7819-31. doi: 10.1093/nar/11.22.7819.
8
Complete nucleotide sequence of the 26S rRNA gene of Physarum polycephalum: its significance in gene evolution.多头绒泡菌26S rRNA基因的完整核苷酸序列：其在基因进化中的意义
Proc Natl Acad Sci U S A. 1983 Jun;80(11):3163-7. doi: 10.1073/pnas.80.11.3163.
9
Sequence and secondary structure of mouse 28S rRNA 5'terminal domain. Organisation of the 5.8S-28S rRNA complex.小鼠28S rRNA 5'末端结构域的序列与二级结构。5.8S - 28S rRNA复合物的组织形式。
Nucleic Acids Res. 1982 Sep 11;10(17):5273-83. doi: 10.1093/nar/10.17.5273.
10
Nucleotide sequence of the region between the 18S rRNA sequence and the 28S rRNA sequence of rat ribosomal DNA.大鼠核糖体DNA的18S rRNA序列与28S rRNA序列之间区域的核苷酸序列。
Nucleic Acids Res. 1982 Jun 25;10(12):3667-80. doi: 10.1093/nar/10.12.3667.

大鼠28 S核糖体RNA的一级和二级结构

Primary and secondary structure of rat 28 S ribosomal RNA.

作者信息

Hadjiolov A A, Georgiev O I, Nosikov V V, Yavachev L P

出版信息

Nucleic Acids Res. 1984 Apr 25;12(8):3677-93. doi: 10.1093/nar/12.8.3677.

DOI:10.1093/nar/12.8.3677
PMID:6328433
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC318778/
Abstract

The primary structure of rat (Rattus norvegicus) 28 S rRNA is determined inferred from the sequence of cloned rDNA fragments. The rat 28 S rRNA contains 4802 nucleotides and has an estimated relative molecular mass (Mr, Na-salt) of 1.66 X 10(6). Several regions of high sequence homology with S. cerevisiae 25 S rRNA are present. These regions can be folded in characteristic base-paired structures homologous to those proposed for Saccharomyces and E. coli. The excess of about 1400 nucleotides in the rat 28 S rRNA (as compared to Saccharomyces 25 S rRNA) is accounted for mainly by the presence of eight distinct G+C-rich segments of different length inserted within the regions of high sequence homology. The G+C content of the four insertions, containing more than 200 nucleotides, is in the range of 78 to 85 percent. All G+C-rich segments appear to form strongly base-paired structures. The two largest G+C-rich segments (about 760 and 560 nucleotides, respectively) are located near the 5'-end and in the middle of the 28 S rRNA molecule. These two segments can be folded into long base-paired structures, corresponding to the ones observed previously by electron microscopy of partly denatured 28 S rRNA molecules.

摘要

大鼠（褐家鼠）28 S rRNA的一级结构是根据克隆的rDNA片段序列推断出来的。大鼠28 S rRNA含有4802个核苷酸，其相对分子质量（Mr，钠盐）估计为1.66×10⁶。与酿酒酵母25 S rRNA存在几个高序列同源性区域。这些区域可以折叠成与酿酒酵母和大肠杆菌中提出的特征性碱基配对结构同源的结构。大鼠28 S rRNA中比酿酒酵母25 S rRNA多约1400个核苷酸，这主要是由于在高序列同源性区域内插入了八个不同长度的富含G+C的独特片段。四个含有超过200个核苷酸的插入片段的G+C含量在78%至85%之间。所有富含G+C的片段似乎都形成了强碱基配对结构。两个最大的富含G+C的片段（分别约为760和560个核苷酸）位于28 S rRNA分子的5'端附近和中间。这两个片段可以折叠成长的碱基配对结构，与之前通过部分变性的28 S rRNA分子的电子显微镜观察到的结构相对应。