游离脂肪酸对淋巴细胞增殖的抑制作用。I. 对小鼠B淋巴细胞和T淋巴细胞的不同影响。
Inhibition of lymphocyte proliferation by free fatty acids. I. Differential effects on mouse B and T lymphocytes.
作者信息
Buttke T M
出版信息
Immunology. 1984 Oct;53(2):235-42.
Saturated and unsaturated long-chain fatty acids were compared for their effects on mitogen-induced DNA synthesis in mouse B and T lymphocytes. At high concentrations (100-120 microM) all of the fatty acids tested were inhibitory to some extent, while at lower concentrations (20-60 microM) only the saturated fatty acids suppressed DNA synthesis. The inhibitory effects of the saturated acids could be reversed by the simultaneous addition of either a cis- or a trans-monounsaturated or a cis,cis-diunsaturated fatty acid. Compared to T cells stimulated with either phytohaemagglutinin or concanavalin A, B cells stimulated with either lipopolysaccharide or 8-bromoguanosine were considerably less susceptible to the inhibitory effects of the saturated fatty acids. These results demonstrate that free fatty acids may be useful tools for delineating the metabolic events involved in B cell and T cell activation.
研究比较了饱和与不饱和长链脂肪酸对小鼠B淋巴细胞和T淋巴细胞有丝分裂原诱导的DNA合成的影响。在高浓度（100 - 120微摩尔）时，所有测试的脂肪酸都有一定程度的抑制作用，而在低浓度（20 - 60微摩尔）时，只有饱和脂肪酸会抑制DNA合成。同时添加顺式或反式单不饱和脂肪酸或顺，顺式双不饱和脂肪酸可逆转饱和脂肪酸的抑制作用。与用植物血凝素或伴刀豆球蛋白A刺激的T细胞相比，用脂多糖或8 - 溴鸟苷刺激的B细胞对饱和脂肪酸的抑制作用的敏感性要低得多。这些结果表明，游离脂肪酸可能是描绘B细胞和T细胞活化所涉及的代谢事件的有用工具。
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