新型大环内酯类抗生素醋酸麦迪霉素（美欧卡霉素）的毒理学研究。第三部分 - 4. 比格犬的慢性毒性：雄性犬26周治疗。
Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miokamycin). Part III-4. Chronic toxicity in beagle dogs: 26-week-treatment in male dogs.
作者信息
Yokota M, Takeda U, Odaki M, Sasaki H, Niizato T, Kawaoto H, Kumagai K, Suzuki H, Suzuki M, Sugiyama N
出版信息
Jpn J Antibiot. 1984 Jul;37(7):1399-416.
Miokamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens. The objective of this study was to determine the chronic toxicity of MOM in male Beagle dogs after repeated oral administration of MOM, non-crystalline solid, for 26 weeks at b.i.d. dosage of 200, 400, 800 and 1,200 mg/kg/day. It is concluded that MOM, non-crystalline solid, did not show any toxic effects in this chronic toxicity study. Therefore, the maximum non-toxic dose is presumed to be 1,200 mg/kg/day or more in male Beagle dogs administered orally at b.i.d. for 26 weeks.
麦白霉素（MOM）是麦迪霉素的衍生物，麦迪霉素是一种从生米卡链霉菌培养液中分离得到的大环内酯类抗生素。本研究的目的是确定雄性比格犬每日两次口服非结晶性固体麦白霉素26周，剂量分别为200、400、800和1200mg/kg/天时的慢性毒性。结论是，在本慢性毒性研究中，非结晶性固体麦白霉素未显示出任何毒性作用。因此，对于每日两次口服给药26周的雄性比格犬，最大无毒剂量推测为1200mg/kg/天或更高。
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