Yokota M, Takeda U, Odaki M, Sasaki H, Niizato T, Kawaoto H, Kumagai K, Suzuki H, Suzuki M, Sugiyama N
Jpn J Antibiot. 1984 Jul;37(7):1383-98.
Miokamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens. The objective of this study was to determine the chronic toxicity of MOM in female Beagle dogs after once daily repeated p.o. administration of MOM, non-crystalline solid, for 26 weeks at daily dosages of 100, 200 and 400 mg/kg. It is concluded that MOM, non-crystalline solid, did not show any toxic effects in this study and the maximum non-toxic dose is presumed to be 400 mg/kg or more in female Beagle dogs administered once daily for 26 weeks.
米欧卡霉素（MOM）是麦迪霉素的衍生物，麦迪霉素是一种从生米卡链霉菌培养液中分离得到的大环内酯类抗生素。本研究的目的是确定在雌性比格犬中，每日一次重复口服给予非结晶性固体米欧卡霉素，连续26周，剂量分别为100、200和400mg/kg时的慢性毒性。得出的结论是，在本研究中，非结晶性固体米欧卡霉素未显示出任何毒性作用，对于每日给药一次、连续26周的雌性比格犬，最大无毒剂量推测为400mg/kg或更高。
