新型大环内酯类抗生素醋酸麦迪霉素（美欧卡霉素）的毒理学研究。第三部分 - 2。比格犬的慢性毒性：雄性犬13周治疗。
Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miokamycin). Part III-2. Chronic toxicity in beagle dogs: 13-week-treatment in male dogs.
作者信息
Yokota M, Takeda U, Odaki M, Sasaki H, Niizato T, Kawaoto H, Kumagai K, Suzuki H, Suzuki M, Sugiyama N
出版信息
Jpn J Antibiot. 1984 Jul;37(7):1377-82.
Miokamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens. The objective of this study was to determine the chronic toxicity of MOM in male Beagle dogs after once daily repeated p.o. administration of MOM, non-crystalline solid, for 13 weeks at daily dosage of 200 and 400 mg/kg. It is concluded that no toxic effects of MOM, non-crystalline solid, were shown in the present studies. Therefore, the maximum non-toxic dose is presumed to be 400 mg/kg or more in male Beagle dogs administered p.o. once daily for 13 weeks.
麦白霉素（MOM）是麦迪霉素的衍生物，麦迪霉素是一种从生米链霉菌培养液中分离得到的大环内酯类抗生素。本研究的目的是确定在雄性比格犬中，每日一次口服给予非结晶性固体麦白霉素，剂量为200和400mg/kg，持续13周后麦白霉素的慢性毒性。结论是，在本研究中未显示非结晶性固体麦白霉素的毒性作用。因此，对于每日口服一次、持续13周的雄性比格犬，最大无毒剂量推测为400mg/kg或更高。
Zotero 插件