Youinou P, Zabbe C, Eveillaud C, Dewitte J D, Kerbourc'h J F, Ferec C, Clavier J
Cancer Immunol Immunother. 1984;18(2):80-1. doi: 10.1007/BF00205738.
Antiperinuclear factor (APF) might be a specific serum rheumatoid factor directed towards keratohyaline granules. It was found to be present in 40 of 79 (50.6%) patients with primary and in 21 of 36 (58.3%) patients with metastatic lung cancer, compared with 12 of 95 (12.6%) sex- and age-matched normal controls. Additionally, APF frequency and titer correlated well with tumor dissemination, even though no relationship could be shown with histopathological type.
抗核周因子（APF）可能是一种针对透明角质颗粒的特异性血清类风湿因子。在79例原发性肺癌患者中有40例（50.6%）检测到该因子，在36例转移性肺癌患者中有21例（58.3%）检测到，而在95例年龄和性别匹配的正常对照者中仅有12例（12.6%）检测到。此外，尽管未发现APF频率和滴度与组织病理学类型有关，但它们与肿瘤播散密切相关。
