寄生虫感染母亲的后代对蠕虫抗原的产前过敏致敏
Prenatal allergic sensitization to helminth antigens in offspring of parasite-infected mothers.
作者信息
Weil G J, Hussain R, Kumaraswami V, Tripathy S P, Phillips K S, Ottesen E A
出版信息
J Clin Invest. 1983 May;71(5):1124-9. doi: 10.1172/jci110862.
Abstract
Total and filaria-specific immunoglobulin E (IgE) levels were studied in cord blood from infants born in Madras, India, where filariasis and intestinal helminth infections are highly endemic. Increased total IgE levels were observed in 82% of 57 cord sera tested (geometric mean 12.6 ng/ml; range 1-1,900 ng/ml). 33 of these sera also contained IgE antibodies specific for filarial antigens as determined by solid-phase radioimmunoassay. Comparison of ratios of filaria-specific IgE to total IgE in paired maternal and cord sera suggested that cord blood IgE was derived from the fetus in most cases and not from transplacental antibody transfer. Our results suggest that prenatal allergic sensitization to helminth parasites occurs in the tropics. Such sensitization may contribute to the heterogeneity in host immune response and disease expression noted in filariasis and other helminth infections.
摘要
在印度马德拉斯出生的婴儿的脐带血中研究了总免疫球蛋白E（IgE）和丝虫特异性IgE水平，该地丝虫病和肠道蠕虫感染非常流行。在检测的57份脐带血清中，82%观察到总IgE水平升高（几何平均值为12.6 ng/ml；范围为1 - 1900 ng/ml）。通过固相放射免疫测定法确定，其中33份血清还含有针对丝虫抗原的IgE抗体。配对的母血和脐带血血清中丝虫特异性IgE与总IgE比值的比较表明，在大多数情况下，脐带血IgE来自胎儿，而非经胎盘的抗体转移。我们的结果表明，在热带地区发生了对蠕虫寄生虫的产前过敏致敏。这种致敏可能导致在丝虫病和其他蠕虫感染中观察到的宿主免疫反应和疾病表现的异质性。
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本文引用的文献
1
THE TRANSMISSION OF CHROMIUM-51 TAGGED MATERNAL ERYTHROCYTES FROM MOTHER TO FETUS.铬-51标记的母体红细胞从母亲到胎儿的传递。
Am J Obstet Gynecol. 1964 Mar 1;88:565-71. doi: 10.1016/0002-9378(64)90881-6.
2
3
Comparison of cord blood immunoglobulin E concentrations and maternal allergy for the prediction of atopic diseases in infancy.脐血免疫球蛋白E浓度与母亲过敏情况对婴儿期特应性疾病预测的比较
J Allergy Clin Immunol. 1980 Jun;65(6):422-30. doi: 10.1016/0091-6749(80)90234-1.
4
IgE responses in human filariasis. I. Quantitation of filaria-specific IgE.人类丝虫病中的IgE反应。I. 丝虫特异性IgE的定量分析
J Immunol. 1981 Oct;127(4):1623-9.
5
The quantitation of parasite-specific human IgG and IgE in sera: evaluation of solid-phase RIA and ELISA methodology.血清中寄生虫特异性人IgG和IgE的定量：固相放射免疫分析和酶联免疫吸附测定方法的评估
J Immunol Methods. 1981;44(1):101-14. doi: 10.1016/0022-1759(81)90111-3.
6
Helminths and the transmammary route of infection.
Parasitology. 1981 Apr;82(Pt 2):335-42. doi: 10.1017/s0031182000057073.
7
8
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9
Recent studies on the regulation of IgE antibody synthesis in experimental animals and man.近期关于实验动物和人类中IgE抗体合成调控的研究。
Immunology. 1980 Sep;41(1):1-24.
10
Basophil releasability in the newborn: factors limiting immunoglobulin E-mediated histamine release.新生儿嗜碱性粒细胞的释放能力：限制免疫球蛋白E介导的组胺释放的因素。
Pediatrics. 1982 Feb;69(2):188-92.
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