恶喹酸对RNA合成的抑制作用与平均DNA超螺旋无关。
Inhibition of RNA synthesis by oxolinic acid is unrelated to average DNA supercoiling.
作者信息
Manes S H, Pruss G J, Drlica K
出版信息
J Bacteriol. 1983 Jul;155(1):420-3. doi: 10.1128/jb.155.1.420-423.1983.
Abstract
Oxolinic acid reduced RNA synthesis rates whether chromosome supercoiling decreased, increased, or remained unchanged. Thus, inhibition of RNA synthesis by oxolinic acid appears to involve factors other than average DNA supercoiling level. Coumermycin A1 caused RNA synthesis rates to increase or decrease roughly in parallel with DNA supercoiling.
摘要
恶喹酸降低RNA合成速率，无论染色体超螺旋是降低、增加还是保持不变。因此，恶喹酸对RNA合成的抑制作用似乎涉及平均DNA超螺旋水平以外的因素。香豆霉素A1使RNA合成速率大致与DNA超螺旋平行地增加或降低。
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