喹诺酮类药物对大肠杆菌温度敏感型dnaB复制突变体的致死作用。
Lethal action of quinolones against a temperature-sensitive dnaB replication mutant of Escherichia coli.
作者信息
Zhao Xilin, Malik Muhammad, Chan Nymph, Drlica-Wagner Alex, Wang Jian-Ying, Li Xinying, Drlica Karl
机构信息
Public Health Research Institute, 225 Warren St., Newark, New Jersey 07103, USA.
出版信息
Antimicrob Agents Chemother. 2006 Jan;50(1):362-4. doi: 10.1128/AAC.50.1.362-364.2006.
Abstract
Inhibition of DNA replication in an Escherichia coli dnaB-22 mutant failed to block quinolone-mediated lethality. Inhibition of protein synthesis by chloramphenicol inhibited nalidixic acid lethality and, to a lesser extent, ciprofloxacin lethality in both dnaB-22 and wild-type cells. Thus, major features of quinolone-mediated lethality do not depend on ongoing replication.
摘要
在大肠杆菌dnaB - 22突变体中抑制DNA复制未能阻止喹诺酮介导的致死性。氯霉素抑制蛋白质合成可抑制萘啶酸的致死性，并且在较小程度上抑制dnaB - 22和野生型细胞中环丙沙星的致死性。因此，喹诺酮介导的致死性的主要特征并不依赖于正在进行的复制。
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