The long-term results of the use of human amnion in the treatment of leg ulcers.

In a retrospective study of 28 patients whose venous leg ulcers had been treated with human amnion prior to split-skin grafting, the rate of recurrence of ulceration was 50% at 1 year. Repeated grafting of ulcers which recurred rapidly after the first skin graft was worthwhile as many then remained healed.