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微生物细胞制造的乙肝病毒抗原有免疫作用,可抵御病毒感染。

Hepatitis B virus antigens made in microbial cells immunise against viral infection.

作者信息

Murray K, Bruce S A, Hinnen A, Wingfield P, van Erd P M, de Reus A, Schellekens H

出版信息

EMBO J. 1984 Mar;3(3):645-50. doi: 10.1002/j.1460-2075.1984.tb01861.x.

DOI:10.1002/j.1460-2075.1984.tb01861.x
PMID:6370689
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC557401/
Abstract

Chimpanzees have been vaccinated successfully against hepatitis B virus with preparations of the viral antigens made in microbial cells by genetic engineering methods.

摘要

通过基因工程方法利用微生物细胞制备的病毒抗原制剂已成功使黑猩猩接种了乙肝疫苗。

相似文献

1
Hepatitis B virus antigens made in microbial cells immunise against viral infection.微生物细胞制造的乙肝病毒抗原有免疫作用,可抵御病毒感染。
EMBO J. 1984 Mar;3(3):645-50. doi: 10.1002/j.1460-2075.1984.tb01861.x.
2
Efficacy of hepatitis B vaccine in chimpanzees given transfusions of highly infective blood.给黑猩猩输注高传染性血液后乙肝疫苗的疗效。
J Infect Dis. 1983 Feb;147(2):327-35. doi: 10.1093/infdis/147.2.327.
3
The protection of chimpanzees against hepatitis B viral infection using a recombinant yeast-derived hepatitis B surface antigen.
Postgrad Med J. 1987;63 Suppl 2:93-6.
4
Human hepatitis B vaccine from recombinant yeast.重组酵母乙型肝炎疫苗
Nature. 1984;307(5947):178-80. doi: 10.1038/307178a0.
5
Immunisation against hepatitis B in man.
Lancet. 1976 Jun 26;1(7974):1367-70. doi: 10.1016/s0140-6736(76)93023-3.
6
Hepatitis-B vaccine. Safety criteria and non-B infection.
Lancet. 1976 Jun 26;1(7974):1396-7. doi: 10.1016/s0140-6736(76)93039-7.
7
Immunization against hepatitis B. A new era in prevention.
CDA J. 1982 Oct;10(10):29-35.
8
A new hepatitis B vaccine containing HBeAg in addition to HBsAg.一种除乙肝表面抗原(HBsAg)外还含有乙肝e抗原(HBeAg)的新型乙肝疫苗。
Dev Biol Stand. 1983;54:13-22.
9
Protective immunisation against hepatitis B with an internal antigen of the virus.使用病毒内部抗原对乙型肝炎进行保护性免疫接种。
J Med Virol. 1987 Oct;23(2):101-7. doi: 10.1002/jmv.1890230202.
10
Safety of hepatitis-B vaccines containing intact 20 nm particles.
Lancet. 1979 Mar 3;1(8114):488. doi: 10.1016/s0140-6736(79)90836-5.

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Laser-captured microglia in the Alzheimer's and Parkinson's brain reveal unique regional expression profiles and suggest a potential role for hepatitis B in the Alzheimer's brain.激光捕获的阿尔茨海默病和帕金森病大脑中的小胶质细胞揭示了独特的区域表达谱,并暗示乙型肝炎在阿尔茨海默病大脑中的潜在作用。
Neurobiol Aging. 2018 Mar;63:12-21. doi: 10.1016/j.neurobiolaging.2017.10.019. Epub 2017 Nov 1.
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Chimeric rabbit/human Fab antibodies against the hepatitis Be-antigen and their potential applications in assays, characterization, and therapy.抗乙型肝炎e抗原的嵌合兔/人Fab抗体及其在检测、表征和治疗中的潜在应用。
J Biol Chem. 2017 Oct 6;292(40):16760-16772. doi: 10.1074/jbc.M117.802272. Epub 2017 Aug 23.
6
Biotechnology and the transformation of vaccine innovation: The case of the hepatitis B vaccines 1968-2000.生物技术与疫苗创新的变革:1968 - 2000年乙肝疫苗的案例
Stud Hist Philos Biol Biomed Sci. 2017 Aug;64:11-21. doi: 10.1016/j.shpsc.2017.05.004. Epub 2017 May 13.
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Induction of humoral and cell-mediated immune responses by hepatitis B virus epitope displayed on the virus-like particles of prawn nodavirus.对虾诺达病毒样颗粒上展示的乙肝病毒表位诱导体液免疫和细胞介导的免疫反应。
Appl Environ Microbiol. 2015 Feb;81(3):882-9. doi: 10.1128/AEM.03695-14. Epub 2014 Nov 21.
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Phage display creates innovative applications to combat hepatitis B virus.噬菌体展示技术为对抗乙型肝炎病毒创造了创新应用。
World J Gastroenterol. 2014 Sep 7;20(33):11650-70. doi: 10.3748/wjg.v20.i33.11650.
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Easing the global burden of diarrhoeal disease: can synthetic biology help?减轻腹泻病的全球负担:合成生物学能有所帮助吗?
Syst Synth Biol. 2013 Sep;7(3):73-8. doi: 10.1007/s11693-013-9114-6. Epub 2013 Jul 20.
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Cellular immune responses in acute hepatitis E virus infection to the viral open reading frame 2 protein.戊型肝炎病毒急性感染中针对病毒开放阅读框2蛋白的细胞免疫反应。
Viral Immunol. 2007 Spring;20(1):56-65. doi: 10.1089/vim.2006.0053.

本文引用的文献

1
A sensitive immunoradiometric assay for the detection of hepatitis B surface antigen.一种用于检测乙型肝炎表面抗原的灵敏免疫放射分析方法。
J Virol Methods. 1980;1(6):311-23. doi: 10.1016/0166-0934(80)90048-8.
2
Accidental hepatitis-B-surface-antigen-positive inoculations. Use of e antigen to estimate infectivity.意外的乙肝表面抗原阳性接种。使用e抗原评估传染性。
Ann Intern Med. 1982 Sep;97(3):367-9. doi: 10.7326/0003-4819-97-3-367.
3
Perinatal transmission of the hepatitis B virus and of the HBV-associated delta agent from mothers to offspring in northern Italy.意大利北部乙型肝炎病毒及与乙肝病毒相关的丁型肝炎病毒的母婴围产期传播情况。
J Med Virol. 1982;9(2):139-48. doi: 10.1002/jmv.1890090209.
4
Synthesis and assembly of hepatitis B virus surface antigen particles in yeast.乙型肝炎病毒表面抗原颗粒在酵母中的合成与组装。
Nature. 1982 Jul 22;298(5872):347-50. doi: 10.1038/298347a0.
5
Hepatitis B virus core antigen: synthesis in Escherichia coli and application in diagnosis.乙肝病毒核心抗原:在大肠杆菌中的合成及其在诊断中的应用。
Proc Natl Acad Sci U S A. 1982 Mar;79(5):1606-10. doi: 10.1073/pnas.79.5.1606.
6
The conversion of hepatitis B core antigen synthesized in E coli into e antigen.在大肠杆菌中合成的乙肝核心抗原向e抗原的转化。
J Med Virol. 1981;8(4):237-43. doi: 10.1002/jmv.1890080404.
7
Hepatitis B vaccine: demonstration of efficacy in a controlled clinical trial in a high-risk population in the United States.乙肝疫苗:在美国高危人群的对照临床试验中疗效的证明
N Engl J Med. 1980 Oct 9;303(15):833-41. doi: 10.1056/NEJM198010093031501.
8
Amplification of expression of hepatitis B surface antigen in 3T3 cells cotransfected with a dominant-acting gene and cloned viral DNA.在与一个显性作用基因和克隆的病毒DNA共转染的3T3细胞中乙型肝炎表面抗原表达的扩增。
Proc Natl Acad Sci U S A. 1982 Mar;79(6):1815-9. doi: 10.1073/pnas.79.6.1815.
9
Excretion of hepatitis B surface antigen particles from mouse cells transformed with cloned viral DNA.从用克隆病毒DNA转化的小鼠细胞中分泌乙型肝炎表面抗原颗粒。
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4549-53. doi: 10.1073/pnas.77.8.4549.
10
Use of and interpretation of results using inocula of hepatitis B virus with known infectivity titers.使用已知感染性滴度的乙型肝炎病毒接种物以及对结果的解读。
J Infect Dis. 1983 Mar;147(3):531-4. doi: 10.1093/infdis/147.3.531.