微生物细胞制造的乙肝病毒抗原有免疫作用，可抵御病毒感染。
Hepatitis B virus antigens made in microbial cells immunise against viral infection.
作者信息
Murray K, Bruce S A, Hinnen A, Wingfield P, van Erd P M, de Reus A, Schellekens H
出版信息
EMBO J. 1984 Mar;3(3):645-50. doi: 10.1002/j.1460-2075.1984.tb01861.x.
Abstract
Chimpanzees have been vaccinated successfully against hepatitis B virus with preparations of the viral antigens made in microbial cells by genetic engineering methods.
摘要
通过基因工程方法利用微生物细胞制备的病毒抗原制剂已成功使黑猩猩接种了乙肝疫苗。
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Hepatitis B virus antigens made in microbial cells immunise against viral infection.微生物细胞制造的乙肝病毒抗原有免疫作用，可抵御病毒感染。
EMBO J. 1984 Mar;3(3):645-50. doi: 10.1002/j.1460-2075.1984.tb01861.x.
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本文引用的文献
1
A sensitive immunoradiometric assay for the detection of hepatitis B surface antigen.一种用于检测乙型肝炎表面抗原的灵敏免疫放射分析方法。
J Virol Methods. 1980;1(6):311-23. doi: 10.1016/0166-0934(80)90048-8.
2
Accidental hepatitis-B-surface-antigen-positive inoculations. Use of e antigen to estimate infectivity.意外的乙肝表面抗原阳性接种。使用e抗原评估传染性。
Ann Intern Med. 1982 Sep;97(3):367-9. doi: 10.7326/0003-4819-97-3-367.
3
Perinatal transmission of the hepatitis B virus and of the HBV-associated delta agent from mothers to offspring in northern Italy.意大利北部乙型肝炎病毒及与乙肝病毒相关的丁型肝炎病毒的母婴围产期传播情况。
J Med Virol. 1982;9(2):139-48. doi: 10.1002/jmv.1890090209.
4
Synthesis and assembly of hepatitis B virus surface antigen particles in yeast.乙型肝炎病毒表面抗原颗粒在酵母中的合成与组装。
Nature. 1982 Jul 22;298(5872):347-50. doi: 10.1038/298347a0.
5
Hepatitis B virus core antigen: synthesis in Escherichia coli and application in diagnosis.乙肝病毒核心抗原：在大肠杆菌中的合成及其在诊断中的应用。
Proc Natl Acad Sci U S A. 1982 Mar;79(5):1606-10. doi: 10.1073/pnas.79.5.1606.
6
The conversion of hepatitis B core antigen synthesized in E coli into e antigen.在大肠杆菌中合成的乙肝核心抗原向e抗原的转化。
J Med Virol. 1981;8(4):237-43. doi: 10.1002/jmv.1890080404.
7
Hepatitis B vaccine: demonstration of efficacy in a controlled clinical trial in a high-risk population in the United States.乙肝疫苗：在美国高危人群的对照临床试验中疗效的证明
N Engl J Med. 1980 Oct 9;303(15):833-41. doi: 10.1056/NEJM198010093031501.
8
Amplification of expression of hepatitis B surface antigen in 3T3 cells cotransfected with a dominant-acting gene and cloned viral DNA.在与一个显性作用基因和克隆的病毒DNA共转染的3T3细胞中乙型肝炎表面抗原表达的扩增。
Proc Natl Acad Sci U S A. 1982 Mar;79(6):1815-9. doi: 10.1073/pnas.79.6.1815.
9
Excretion of hepatitis B surface antigen particles from mouse cells transformed with cloned viral DNA.从用克隆病毒DNA转化的小鼠细胞中分泌乙型肝炎表面抗原颗粒。
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4549-53. doi: 10.1073/pnas.77.8.4549.
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Use of and interpretation of results using inocula of hepatitis B virus with known infectivity titers.使用已知感染性滴度的乙型肝炎病毒接种物以及对结果的解读。
J Infect Dis. 1983 Mar;147(3):531-4. doi: 10.1093/infdis/147.3.531.
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