Pozza G, Spotti D, Micossi P, Cristallo M, Melandri M, Piatti P M, Monti L D, Pontiroli A E
Br Med J (Clin Res Ed). 1983 Jan 22;286(6361):255-6. doi: 10.1136/bmj.286.6361.255.
Attempts to achieve a fair metabolic equilibrium in a young woman with brittle diabetes by continuous subcutaneous, intramuscular, and continuous intravenous administration of insulin were unsuccessful. Continuous intraperitoneal administration of insulin through a permanently inserted polyethylene catheter connected to an open-loop peristaltic pump led to an appreciable improvement in mean blood glucose concentration, mean amplitude of glycaemic excursions, and M value and to normalisation of intermediate metabolic products. The peritoneal catheter was well tolerated for over 120 days without appreciable adverse effects. This case suggests that long-term intraperitoneal administration of insulin is a feasible therapeutic approach in the management of brittle diabetes.
通过持续皮下、肌肉和持续静脉注射胰岛素，试图在一名脆性糖尿病年轻女性患者身上实现公平的代谢平衡，但未成功。通过连接到开环蠕动泵的永久插入的聚乙烯导管持续腹腔内注射胰岛素，使平均血糖浓度、血糖波动平均幅度和M值有了明显改善，并使中间代谢产物正常化。腹膜导管耐受良好，超过120天没有明显不良反应。该病例表明，长期腹腔内注射胰岛素是治疗脆性糖尿病的一种可行的治疗方法。
