Cochet B, Jung A, Griessen M, Bartholdi P, Schaller P, Donath A
Gastroenterology. 1983 May;84(5 Pt 1):935-40.
The effect of lactose on intestinal calcium absorption was studied in 12 normal-lactase subjects and 7 lactase-deficient subjects. Calcium absorption was compared by using the double isotope technique with or without the presence of an oral load of 50 g of lactose in each subject. The kinetic parameters were measured by the deconvolution method. In the normal lactase group, the lactose prolonged the duration of absorption at a maximum rate and therefore increased the total fractional calcium absorption from 0.224 +/- 0.039 to 0.356 +/- 0.076 (p less than 0.001). In the lactase-deficient subjects, the lactose decreased the total absorption from 0.255 +/- 0.039 to 0.209 +/- 0.032 (p less than 0.005); this effect resulted in a decrease of the maximum absorption rate. There was no significant difference between the two groups when calcium was ingested alone. These results indicate that the effect of lactose on calcium absorption is dependent on intestinal lactase activity.
在12名乳糖酶正常的受试者和7名乳糖酶缺乏的受试者中研究了乳糖对肠道钙吸收的影响。采用双同位素技术，比较了每位受试者在有或无50克乳糖口服负荷情况下的钙吸收情况。通过反卷积法测量动力学参数。在乳糖酶正常组中，乳糖延长了最大吸收率下的吸收持续时间，因此使总钙吸收分数从0.224±0.039增加到0.356±0.076（p<0.001）。在乳糖酶缺乏的受试者中，乳糖使总吸收从0.255±0.039降至0.209±0.032（p<0.005）；这种作用导致最大吸收率降低。单独摄入钙时，两组之间无显著差异。这些结果表明，乳糖对钙吸收的影响取决于肠道乳糖酶活性。
