Shows T B, Sakaguchi A Y, Naylor S L, Goedell D V, Lawn R M
Science. 1982 Oct 22;218(4570):373-4. doi: 10.1126/science.6181564.
At least ten leukocyte interferon genes and the single known fibroblast interferon gene have been localized on the pter leads to q12 region of human chromosome 9. Gene mapping was accomplished by blot hybridization of cloned interferon complementary DNA to DNA from human-mouse cell hybrids with a translocation involving human chromosome 9. Supporting evidence suggests these genes are clustered.
至少十种白细胞干扰素基因和唯一已知的成纤维细胞干扰素基因已定位在人类9号染色体从pter到q12的区域。基因定位是通过将克隆的干扰素互补DNA与来自涉及人类9号染色体易位的人-鼠细胞杂种的DNA进行印迹杂交来完成的。支持性证据表明这些基因是成簇的。
