Russell R M, Rosenberg I H, Wilson P D, Iber F L, Oaks E B, Giovetti A C, Otradovec C L, Karwoski P A, Press A W
Am J Clin Nutr. 1983 Jul;38(1):64-70. doi: 10.1093/ajcn/38.1.64.
The effect of ethanol on the kinetics of folic acid urinary excretion was studied in five chronic alcoholic patients who were maintained in a folate replete state. For 17 days, 95% ethanol was administered orally at 2-h intervals (X9). The folate pool(s) were labeled with the tritium labeled pteroyl glutamic acid at the start of the period of ethanol ingestion and at the start of a control abstinent period. The 24-h urine volume did not change with consumption of ethanol. Total urinary folate excretion was significantly greater by 20 to 40% in four of five patients during the ethanol administration period (p less than 0.05). The fall-off in urinary radioactivity corrected for total folate excretion (dpm/microgram Lactobacillus casei folate) was resolved into a biexponential decay with two distinct slopes. Ethanol caused the slope of the second component to flatten significantly with mean t1/2 of 63.7 days on ethanol versus 9.6 days off (p less than 0.05). These kinetic results are consistent with the known interference by ethanol of folate utilization in a functional tissue pool.
在五名维持叶酸充足状态的慢性酒精中毒患者中，研究了乙醇对叶酸尿排泄动力学的影响。在17天的时间里，每隔2小时口服95%乙醇（X9）。在乙醇摄入期开始时以及对照戒酒期开始时，用氚标记的蝶酰谷氨酸标记叶酸池。乙醇摄入后24小时尿量没有变化。在五名患者中的四名患者的乙醇给药期间，总尿叶酸排泄量显著增加了20%至40%（p<0.05）。校正总叶酸排泄量后的尿放射性下降（每分钟衰变数/微克干酪乳杆菌叶酸）分解为具有两个不同斜率的双指数衰减。乙醇导致第二成分的斜率显著变平，乙醇期间的平均半衰期为63.7天，戒酒期间为9.6天（p<0.05）。这些动力学结果与已知的乙醇对功能性组织池中叶酸利用的干扰一致。
