Ellul-Micallef R
Thorax. 1983 Jul;38(7):527-30. doi: 10.1136/thx.38.7.527.
The effects of sodium cromoglycate and ketotifen were studied in a group of 20 patients in whom fish repeatedly provoked an attack of wheezing and dyspnoea within one hour of its being eaten. Fish ingestion resulted in a fall in forced expiratory volume in one second (FEV1) of at least 15%. All patients had a weal greater than 4 mm in response to fish antigen in the skinprick test and most had blood eosinophilia and raised serum IgE levels. Administration of drugs and placebos was carried out under double-blind conditions, in a randomised fashion, on different days. Cromoglycate blocked the fall in FEV1 either completely or significantly in 16 patients. Ketotifen did not appear to have any significant effect in the group as a whole.
对一组20名患者进行了色甘酸钠和酮替芬的疗效研究，这些患者在食用鱼类后1小时内反复出现喘息和呼吸困难发作。摄入鱼类导致一秒用力呼气量（FEV1）至少下降15%。所有患者在皮肤点刺试验中对鱼类抗原的反应出现大于4毫米的风团，大多数患者有血液嗜酸性粒细胞增多和血清IgE水平升高。药物和安慰剂的给药在双盲条件下随机进行，且在不同日期进行。色甘酸钠在16名患者中完全或显著地阻止了FEV1的下降。酮替芬在整个组中似乎没有任何显著效果。
