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小肠细菌污染是老年人隐匿性吸收不良的一个重要原因。

Bacterial contamination of the small intestine is an important cause of occult malabsorption in the elderly.

作者信息

McEvoy A, Dutton J, James O F

出版信息

Br Med J (Clin Res Ed). 1983 Sep 17;287(6395):789-93. doi: 10.1136/bmj.287.6395.789.

Abstract

A study was conducted to examine the contribution that occult malabsorption makes to malnutrition among elderly patients admitted to an acute geriatric ward. Malnutrition was defined by anthropometric, haematological, and biochemical measurements. Out of 490 patients, 55--many of whom had presented with non-gastrointestinal symptoms--were found to be malnourished. In 31 poor diet alone was probably the cause, but in the remaining 24 patients previously unrecognised malabsorption was detected. Of these patients, 17 were found to have bacterial contamination of the small bowel (nine with duodenojejunal diverticula, four after gastric surgery, and four diagnosed as contamination with "no sump"). In 10 patients contamination was confirmed by culture of intestinal juice: Escherichia coli was predominant in nine cases, and anaerobic organisms in one. Small bowel bacterial overgrowth without a "blind loop" or obvious underlying cause has not previously been fully proved in the elderly. Coeliac disease was detected in two patients, and chronic pancreatitis in two. Occult malabsorption is an important cause of malnutrition in the elderly. Such malnutrition not infrequently occurs in geriatric patients presenting to hospital with non-specific symptoms of physical deterioration.

摘要

开展了一项研究,以调查隐性吸收不良对入住急性老年病房的老年患者营养不良的影响。通过人体测量、血液学和生化测量来定义营养不良。在490名患者中,发现55名营养不良,其中许多人表现为非胃肠道症状。在31名患者中,可能仅饮食不良是原因,但在其余24名患者中,检测到先前未被识别的吸收不良。在这些患者中,17名被发现小肠有细菌污染(9名患有十二指肠空肠憩室,4名接受胃手术后,4名被诊断为“无贮液池”污染)。10名患者通过肠液培养证实有污染:9例以大肠杆菌为主,1例以厌氧菌为主。小肠细菌过度生长而无“盲袢”或明显潜在病因在老年人中以前尚未得到充分证实。两名患者检测出乳糜泻,两名患者检测出慢性胰腺炎。隐性吸收不良是老年人营养不良的重要原因。这种营养不良在因身体衰退的非特异性症状入院的老年患者中并不少见。

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