采用Wellcogen b型流感嗜血杆菌、肺炎链球菌和脑膜炎奈瑟菌（ACYW135）乳胶凝集试验检测体液中的细菌抗原。
Detection of bacterial antigens in body fluids with the Wellcogen Haemophilus influenzae b, Streptococcus pneumoniae, and Neisseria meningitidis (ACYW135) latex agglutination tests.
作者信息
Ingram D L, Pearson A W, Occhiuti A R
出版信息
J Clin Microbiol. 1983 Nov;18(5):1119-21. doi: 10.1128/jcm.18.5.1119-1121.1983.
Abstract
The Wellcogen Haemophilus influenzae b, Streptococcus pneumoniae, and Neisseria meningitidis (ACYW135) latex agglutination tests (Wellcome Diagnostics, Dartford, England) were evaluated as methods to detect bacterial antigens in cerebrospinal fluid (CSF), urine, and serum from patients with meningitis or sepsis. Antigen was detected in 92% of CSFs from H. influenzae b, 100% of CSFs from N. meningitidis groups A and Y, 36% of CSFs from N. meningitidis group C, and 69% of CSFs from pneumococcal meningitidis patients. Serum samples presented a problem, with a few false-positive or possible cross-reactions. The Wellcogen latex agglutination tests were more sensitive than the Bactogen (H. influenzae type b) latex agglutination test and the Phadebact (S. pneumoniae) coagglutination test.
摘要
对Wellcogen b型流感嗜血杆菌、肺炎链球菌和脑膜炎奈瑟菌（ACYW135）乳胶凝集试验（英国达特福德威康诊断公司）进行了评估，作为检测脑膜炎或败血症患者脑脊液（CSF）、尿液和血清中细菌抗原的方法。在b型流感嗜血杆菌患者92%的脑脊液、A群和Y群脑膜炎奈瑟菌患者100%的脑脊液、C群脑膜炎奈瑟菌患者36%的脑脊液以及肺炎球菌脑膜炎患者69%的脑脊液中检测到抗原。血清样本存在问题，有一些假阳性或可能的交叉反应。Wellcogen乳胶凝集试验比Bactogen（b型流感嗜血杆菌）乳胶凝集试验和Phadebact（肺炎链球菌）协同凝集试验更敏感。
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