Satake K, Mukai R, Kato Y, Shim K, Umeyama K
Clin Oncol. 1984 Mar;10(1):27-34.
Experimental pancreatic carcinoma induced by BHP in hamsters and by DMBA in rats are compared with human pancreatic carcinoma. Tubular adenocarcinoma and papillary adenocarcinoma in human pancreas and hamster pancreas appeared to be similar. However, poorly differentiated adenocarcinoma and acinar cell carcinoma were not observed in the experimental hamster model. Poorly differentiated adenocarcinoma and acinar cell carcinoma in human and rat pancreas were similar but experimentally induced papillary adenocarcinoma and cystoadenocarcinoma were not observed in the rat. Mucin producing cells were usually observed in human and experimental pancreatic carcinoma in the hamster but were rarely noted in the rat. These results indicate that experimental pancreatic carcinoma either in rats or hamsters is a good model for the understanding of both the histogenesis and the carcinogenesis of human pancreatic carcinoma.
将用BHP诱导的仓鼠实验性胰腺癌和用DMBA诱导的大鼠实验性胰腺癌与人类胰腺癌进行比较。人类胰腺和仓鼠胰腺中的管状腺癌和乳头状腺癌似乎相似。然而，在实验性仓鼠模型中未观察到低分化腺癌和腺泡细胞癌。人类和大鼠胰腺中的低分化腺癌和腺泡细胞癌相似，但在大鼠中未观察到实验诱导的乳头状腺癌和囊腺癌。在人类和仓鼠的实验性胰腺癌中通常可观察到产生黏液的细胞，但在大鼠中很少见到。这些结果表明，大鼠或仓鼠的实验性胰腺癌都是理解人类胰腺癌组织发生和致癌过程的良好模型。
