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血清C反应蛋白的快速半定量评估能否用于细菌感染的管理？

Can the rapid semiquantitative estimation of serum C reactive protein be adapted for the management of bacterial infection?

作者信息

Richards N P, Elliott T S, Powell R J, O'Callaghan C, Franklin P

出版信息

J Clin Pathol. 1985 Apr;38(4):464-7. doi: 10.1136/jcp.38.4.464.

DOI:10.1136/jcp.38.4.464
PMID:3988960
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC499180/
Abstract

Serum C reactive protein concentrations measured by a laboratory based assay were compared with the semiquantitative results obtained with a visual agglutination method (Well-cotest, CRP kit). Using this agglutination kit, diluting serum 1/10 and 1/20 gave C reactive protein results which could be of more clinical value than those obtained using the 1/2, 1/4, 1/8, and 1/16 dilutions recommended by the manufacturers. The kit was also used on the ward by junior medical staff, who showed that after minimal training reproducible serum C reactive protein results could be obtained.

摘要

将通过实验室检测方法测得的血清C反应蛋白浓度与采用视觉凝集法（Well-cotest，CRP试剂盒）获得的半定量结果进行比较。使用该凝集试剂盒，将血清稀释1/10和1/20时得到的C反应蛋白结果可能比制造商推荐的1/2、1/4、1/8和1/16稀释度所获得的结果更具临床价值。该试剂盒也由初级医务人员在病房使用，他们表明经过最少的培训就能获得可重复的血清C反应蛋白结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e882/499180/c1e5c001853d/jclinpath00187-0104-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e882/499180/c1e5c001853d/jclinpath00187-0104-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e882/499180/c1e5c001853d/jclinpath00187-0104-a.jpg

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本文引用的文献

1
Interference by rheumatoid factor with the detection of C-reactive protein by the latex agglutination method.类风湿因子对乳胶凝集法检测C反应蛋白的干扰。
J Rheumatol. 1980 May-Jun;7(3):279-87.
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Early diagnosis of neonatal sepsis.新生儿败血症的早期诊断
Pediatrics. 1980 May;65(5):1036-41.
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Serial study of C-reactive protein during infection in leukaemia.白血病感染期间C反应蛋白的系列研究
J Clin Pathol. 1981 Mar;34(3):263-6. doi: 10.1136/jcp.34.3.263.
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Use of serum C-reactive protein in differentiating septic from aseptic meningitis in children.
J Pediatr. 1983 May;102(5):718-20. doi: 10.1016/s0022-3476(83)80242-x.
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Serial study of C reactive protein in neonatal septicaemia.新生儿败血症中C反应蛋白的系列研究
Arch Dis Child. 1984 May;59(5):435-8. doi: 10.1136/adc.59.5.435.
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C reactive protein concentrations in neonates: determination by a latex enhanced immunoassay.新生儿C反应蛋白浓度：通过乳胶增强免疫测定法测定
J Clin Pathol. 1984 Sep;37(9):1027-8. doi: 10.1136/jcp.37.9.1027.
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C reactive protein rapid assay techniques for monitoring resolution of infection in immunosuppressed patients.用于监测免疫抑制患者感染消退情况的C反应蛋白快速检测技术。
J Clin Pathol. 1984 Jul;37(7):821-5. doi: 10.1136/jcp.37.7.821.
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C-reactive protein for rapid monitoring of infections of the central nervous system.C反应蛋白用于快速监测中枢神经系统感染
Lancet. 1982 May 1;1(8279):980-2. doi: 10.1016/s0140-6736(82)91989-4.
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The clinical usefulness of C-reactive protein (CRP) determinations in bacterial meningitis and septicemia in infancy.C反应蛋白（CRP）测定在婴儿细菌性脑膜炎和败血症中的临床应用价值。
Acta Paediatr Scand. 1974 May;63(3):381-8. doi: 10.1111/j.1651-2227.1974.tb04814.x.
10
C-reactive protein (CRP) in early diagnosis of neonatal septicemia.C反应蛋白（CRP）在新生儿败血症早期诊断中的应用
Acta Paediatr Scand. 1979 Nov;68(6):825-31. doi: 10.1111/j.1651-2227.1979.tb08219.x.