Yasuda N, Shimada H, Kanoh T, Uchino H
Clin Exp Immunol. 1984 Aug;57(2):351-7.
The synthesis of J chain and the ultrastructural changes in chronic lymphocytic leukaemia (CLL) cells during in vitro cultures stimulated with PWM and/or allogenic T cells were investigated by immunoelectron microscopy, radioimmunoassay and anti-idiotype antibodies, in an attempt to demonstrate changes in the maturation stage of CLL cells. The cells from four patients showed the induction of J chain synthesis in parallel with the increase of Ig synthesis. Two of revealed cytological transformations, in which CLL cells resembled immunoblasts or plasmacytoid cells. These findings suggest that some CLL cells are not 'frozen' within the original maturation stage and can be induced to differentiate to a more mature stage.
通过免疫电子显微镜、放射免疫测定和抗独特型抗体，研究了在经PWM和/或同种异体T细胞刺激的体外培养过程中，慢性淋巴细胞白血病（CLL）细胞中J链的合成及超微结构变化，旨在证明CLL细胞成熟阶段的变化。来自4例患者的细胞显示J链合成的诱导与Ig合成的增加平行。其中2例出现细胞学转化，CLL细胞类似于免疫母细胞或浆细胞样细胞。这些发现表明，一些CLL细胞并非“停滞”在原始成熟阶段，而是可以被诱导分化至更成熟阶段。
